Is Bupivacaine + Epinephrine approved by the US FDA?

Drugs@FDA lists 15 application product lines for Bupivacaine + Epinephrine, including MARCAINE HYDROCHLORIDE W/ EPINEPHRINE (Prescription); MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE (Prescription); SENSORCAINE (Prescription); SENSORCAINE (Prescription); SENSORCAINE (Prescription).

Active substances

Bupivacaine + Epinephrine

US FDA 15
Health Canada 5
NHS prices 2

Open in the medicines table

US FDA United States — FDA approvals (Drugs@FDA)

Product	Strength	Form · route	Applicant	Status	First approved
MARCAINE HYDROCHLORIDE W/ EPINEPHRINE	0.25%;0.0091MG/ML; 0.5%;0.0091MG/ML	injectable · injection	HOSPIRA	Prescription	3 Oct 1972
MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE	0.5%;0.0091MG/ML; 0.75%;0.0091MG/ML; 0.25%;0.0091MG/ML	injectable · injection	HOSPIRA	Prescription	3 Oct 1972
SENSORCAINE	0.5%;0.0091MG/ML; 0.75%;0.0091MG/ML	injectable · injection	FRESENIUS KABI USA	Prescription	30 Dec 1981
SENSORCAINE	0.25%;0.0091MG/ML	injectable · injection	FRESENIUS KABI USA	Prescription	13 Oct 1987
SENSORCAINE	0.25%;0.0091MG/ML	injectable · injection	FRESENIUS KABI USA	Prescription	13 Oct 1987
SENSORCAINE	0.5%;0.0091MG/ML	injectable · injection	FRESENIUS KABI USA	Prescription	13 Oct 1987
BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE	0.25%;0.005MG/ML	injectable · injection	HOSPIRA	Prescription	16 Jun 1988
BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE	0.25%;0.005MG/ML	injectable · injection	HOSPIRA	Prescription	16 Jun 1988
BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE	0.5%;0.005MG/ML	injectable · injection	HOSPIRA	Prescription	16 Jun 1988
BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE	0.5%;0.005MG/ML	injectable · injection	HOSPIRA	Prescription	16 Jun 1988
VIVACAINE	0.5%;0.0091MG/ML	injectable · injection	SEPTODONT	Prescription	27 Sep 2006
BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE	0.5%;0.0091MG/ML	injectable · injection	HOSPIRA	Discontinued	13 Jul 1983
BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE	0.25%;0.005MG/ML	injectable · injection	HOSPIRA	Discontinued	16 Jun 1988
BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE	0.5%;0.005MG/ML	injectable · injection	HOSPIRA	Discontinued	16 Jun 1988
BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE	0.75%;0.005MG/ML	injectable · injection	HOSPIRA	Discontinued	16 Jun 1988

Canada Canada — marketed products (Health Canada)

Brand	DIN	Strength	Form · route	Company
MARCAINE	02474247	0.0091 MG / ML; 5 MG / ML	SOLUTION · BLOCK/INFILTRATION	SEPTODONT INC
MARCAINE E	02241915	0.182 MG / 20 ML; 50 MG / 20 ML	SOLUTION · BLOCK/INFILTRATION; EPIDURAL	PFIZER CANADA ULC
MARCAINE E	02241916	100 MG / 20 ML; 0.182 MG / 20 ML	SOLUTION · EPIDURAL; BLOCK/INFILTRATION	PFIZER CANADA ULC
SENSORCAINE WITH EPINEPHRINE	01976184	5 MCG / ML; 2.5 MG / ML	SOLUTION · EPIDURAL; BLOCK/INFILTRATION	ASPEN PHARMACARE CANADA INC.
SENSORCAINE WITH EPINEPHRINE	01976206	5 MCG / ML; 5 MG / ML	SOLUTION · BLOCK/INFILTRATION; EPIDURAL	ASPEN PHARMACARE CANADA INC.

Prices — United States and England

Source	Product as listed	Price	Unit / pack	Date
NHS Drug Tariff	Bupivacaine 25mg/10ml (0.25%) / Adrenaline (base) 50micrograms/10ml (1 in 200,000) solution for injection ampoules	£46.00	10 ampoule	1 Oct 2026
NHS Drug Tariff	Bupivacaine 50mg/10ml (0.5%) / Adrenaline (base) 50micrograms/10ml (1 in 200,000) solution for injection ampoules	£51.75	10 ampoule	1 Oct 2026

NADAC: average price US retail pharmacies pay to buy the medicine. NHS Drug Tariff Part VIIIA: basic price reimbursed to pharmacies in England and Wales.

Components

Values as published by each source: SFDA human drug list (4-2026, as published by the Council of Health Insurance; indications from the CHI Daman Drug Formulary), Drugs@FDA, EMA medicines data, Health Canada Drug Product Database (Open Government Licence – Canada), CMS NADAC, NHS Drug Tariff Part VIIIA (NHSBSA Copyright, Open Government Licence v3.0), WHO Model List of Essential Medicines (CC BY 3.0 IGO; regrouped by active substance, not created by WHO), EMA PRAC, US FDA safety-related labeling changes and MHRA Drug Safety Update (Open Government Licence v3.0). Sources and reuse. Not a substitute for the official registers or the product information.