Active substance
Chlordiazepoxide
- US FDA 83
- Health Canada 1
- US price lines 3
- NHS prices 2
- Safety 6
US FDA United States — FDA approvals (Drugs@FDA)
| Product | Strength | Form · route | Applicant | Status | First approved |
|---|---|---|---|---|---|
| CHLORDIAZEPOXIDE HYDROCHLORIDE | 10MG | capsule · oral | BARR | Prescription | 10 Jun 1976 |
| CHLORDIAZEPOXIDE HYDROCHLORIDE | 5MG | capsule · oral | BARR | Prescription | 10 Jun 1976 |
| CHLORDIAZEPOXIDE HYDROCHLORIDE | 25MG | capsule · oral | BARR | Prescription | 10 Jun 1976 |
| CHLORDIAZEPOXIDE HYDROCHLORIDE | 10MG | capsule · oral | CHARTWELL RX | Prescription | 15 Jun 1976 |
| CHLORDIAZEPOXIDE HYDROCHLORIDE | 5MG | capsule · oral | CHARTWELL RX | Prescription | 15 Jun 1976 |
| CHLORDIAZEPOXIDE HYDROCHLORIDE | 25MG | capsule · oral | CHARTWELL RX | Prescription | 15 Jun 1976 |
| LIBRIUM | 5MG | capsule · oral | BAUSCH | Prescription | 21 Sep 1977 |
| LIBRIUM | 10MG | capsule · oral | BAUSCH | Prescription | 21 Sep 1977 |
| LIBRIUM | 25MG | capsule · oral | BAUSCH | Prescription | 21 Sep 1977 |
| LIBRIUM | 10MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**; 5MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**; 25MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | capsule · oral | VALEANT PHARM INTL | Discontinued | 24 Feb 1960 |
| LIBRIUM | 100MG/AMP | injectable · injection | BAUSCH | Discontinued | 21 Jul 1961 |
| CHLORDIAZEPOXIDE HYDROCHLORIDE | 25MG | capsule · oral | IVAX SUB TEVA PHARMS | Discontinued | 7 Mar 1975 |
| CHLORDIAZEPOXIDE HYDROCHLORIDE | 5MG | capsule · oral | IVAX SUB TEVA PHARMS | Discontinued | 7 Mar 1975 |
| CHLORDIAZEPOXIDE HYDROCHLORIDE | 10MG | capsule · oral | IVAX SUB TEVA PHARMS | Discontinued | 7 Mar 1975 |
| CHLORDIAZEPOXIDE HYDROCHLORIDE | 10MG | capsule · oral | USL PHARMA | Discontinued | 24 Feb 1976 |
| CHLORDIAZEPOXIDE HYDROCHLORIDE | 5MG | capsule · oral | USL PHARMA | Discontinued | 24 Feb 1976 |
| CHLORDIAZEPOXIDE HYDROCHLORIDE | 25MG | capsule · oral | USL PHARMA | Discontinued | 24 Feb 1976 |
| LYGEN | 10MG | capsule · oral | ALRA | Discontinued | 21 Apr 1976 |
| LYGEN | 5MG | capsule · oral | ALRA | Discontinued | 21 Apr 1976 |
| LYGEN | 25MG | capsule · oral | ALRA | Discontinued | 21 Apr 1976 |
| CHLORDIAZACHEL | 10MG | capsule · oral | RACHELLE | Discontinued | 11 May 1976 |
| CHLORDIAZACHEL | 5MG | capsule · oral | RACHELLE | Discontinued | 11 May 1976 |
| CHLORDIAZACHEL | 25MG | capsule · oral | RACHELLE | Discontinued | 11 May 1976 |
| CHLORDIAZEPOXIDE HYDROCHLORIDE | 10MG | capsule · oral | ROXANE | Discontinued | 2 Jul 1976 |
| CHLORDIAZEPOXIDE HYDROCHLORIDE | 5MG | capsule · oral | ROXANE | Discontinued | 2 Jul 1976 |
58 more — full table
Canada Canada — marketed products (Health Canada)
| Brand | DIN | Strength | Form · route | Company |
|---|---|---|---|---|
| CHLORDIAZEPOXIDE | 00522996 | 25 MG | CAPSULE · ORAL | AA PHARMA INC |
Prices — United States and England
| Source | Product as listed | Price | Unit / pack | Date |
|---|---|---|---|---|
| US NADAC | CHLORDIAZEPOXIDE 10 MG CAPSULE | $0.14347 | per EA | 23 Sep 2026 |
| US NADAC | CHLORDIAZEPOXIDE 25 MG CAPSULE | $0.15817 | per EA | 23 Sep 2026 |
| US NADAC | CHLORDIAZEPOXIDE 5 MG CAPSULE | $0.18674 | per EA | 23 Sep 2026 |
| NHS Drug Tariff | Chlordiazepoxide 10mg capsules | £94.55 | 100 capsule | 1 Oct 2026 |
| NHS Drug Tariff | Chlordiazepoxide 5mg capsules | £125.45 | 100 capsule | 1 Oct 2026 |
NADAC: average price US retail pharmacies pay to buy the medicine. NHS Drug Tariff Part VIIIA: basic price reimbursed to pharmacies in England and Wales.
Safety signals and safety-related labeling changes
- EMA PRAC 7 May 2026 PRAC signal: Miscarriage associated with in utero exposure to benzodiazepines (including fixed-dose combinations)
Action for MAH: update of the product information: No - EMA PRAC 7 May 2026 PRAC signal: Miscarriage associated with in utero exposure to benzodiazepines (including fixed-dose combinations)
Action for MAH: update of the product information: No - EMA PRAC 7 May 2026 PRAC signal: Miscarriage associated with in utero exposure to benzodiazepines (including fixed-dose combinations)
Action for MAH: update of the product information: No - US FDA 24 Jun 2025 LIMBITROL — safety-related labeling change
Labeling sections changed: Boxed Warning; Warnings and Precautions; Adverse Reactions; Drug Interactions; Use in Specific Populations; Patient Counseling Information / Patient Information / Medication Guide - US FDA 13 Jan 2023 LIBRAX — safety-related labeling change
Labeling sections changed: Boxed Warning; Warnings and Precautions; Drug Interactions; Patient Counseling Information / Patient Information / Medication Guide - US FDA 16 Dec 2016 LIBRIUM — safety-related labeling change
Labeling sections changed: Boxed Warning; Warnings and Precautions; Drug Interactions; Patient Counseling Information / Patient Information / Medication Guide
Combinations containing Chlordiazepoxide
Values as published by each source: SFDA human drug list (4-2026, as published by the Council of Health Insurance; indications from the CHI Daman Drug Formulary), Drugs@FDA, EMA medicines data, Health Canada Drug Product Database (Open Government Licence – Canada), CMS NADAC, NHS Drug Tariff Part VIIIA (NHSBSA Copyright, Open Government Licence v3.0), WHO Model List of Essential Medicines (CC BY 3.0 IGO; regrouped by active substance, not created by WHO), EMA PRAC, US FDA safety-related labeling changes and MHRA Drug Safety Update (Open Government Licence v3.0). Sources and reuse. Not a substitute for the official registers or the product information.