Active substance
Chlorhexidine
- SFDA 5
- US FDA 33
- Health Canada 28
- US price lines 4
- NHS prices 10
- WHO EML 2
- Safety 21
SFDA Saudi Arabia — SFDA human drug list
| Trade name | Strength | Form · route | Pack | Public price | Type | Company | Status |
|---|---|---|---|---|---|---|---|
| HEXIDINE SOLN 1%V-V MOUTH WASH | 1 % | Mouthwash · Topical | 1 Bottle | SAR 5.70 | NCE · OTC | Hikma Pharmaceuticals PLC | Withdrawn by MAH · Not Marketed |
| HIBISCRUB SOLUTION 4% W-V | 4 % | Solution · Topical | 1 Bottle | SAR 9.00 | NCE · OTC | AstraZeneca | Withdrawn by MAH · Not Marketed |
| HIBISCRUB SOLUTION 4% W-V | 4 % | Solution · Topical | 1 Bottle | SAR 16.05 | NCE · OTC | AstraZeneca | Withdrawn by MAH · Not Marketed |
| HIBITANE OBESTET. CREAM 1% | 1 % | Cream · Topical | 1 Tube | SAR 6.85 | NCE · OTC | AstraZeneca | Withdrawn by MAH · Not Marketed |
| URO-TAINER CHLORHEXIDINE1:5000 SOLN | 0.025 % | Solution for injection · Intravenous use | 1 Bottle | SAR 10.55 | Generic · OTC | B. BRAUN | Withdrawn by MAH · Not Marketed |
US FDA United States — FDA approvals (Drugs@FDA)
| Product | Strength | Form · route | Applicant | Status | First approved |
|---|---|---|---|---|---|
| HIBICLENS | 4% | solution · topical | MOLNLYCKE HLTH | Over-the-counter | 17 Sep 1976 |
| HIBISTAT | 0.5% | solution · topical | MOLNLYCKE HLTH | Over-the-counter | 23 May 1980 |
| DYNA-HEX 4 | 4% | solution · topical | XTTRIUM | Over-the-counter | 24 Dec 1984 |
| EXIDINE | 4% | aerosol, metered · topical | XTTRIUM | Over-the-counter | 24 Dec 1984 |
| DYNA-HEX 2 | 2% | solution · topical | XTTRIUM | Over-the-counter | 17 Dec 1985 |
| CIDA-STAT | 2% | solution · topical | ECOLAB | Over-the-counter | 22 Jul 1986 |
| CHG SCRUB | 4% | solution · topical | ECOLAB | Over-the-counter | 22 Jul 1986 |
| PERIDEX | 0.12% | solution · dental | SOLVENTUM | Prescription | 13 Aug 1986 |
| BIOSCRUB | 4% | sponge · topical | GRIFFEN | Over-the-counter | 31 Mar 1989 |
| CHLORHEXIDINE GLUCONATE | 4% | sponge · topical | BECTON DICKINSON | Over-the-counter | 24 Oct 1989 |
| CHLORHEXIDINE GLUCONATE | 0.12% | solution · dental | PHARM ASSOC | Prescription | 15 Dec 1995 |
| CHLORHEXIDINE GLUCONATE | 0.12% | solution · dental | LYNE | Prescription | 28 Dec 1995 |
| CHLORHEXIDINE GLUCONATE | 0.75% | solution · topical | BAJAJ | Over-the-counter | 11 Sep 1997 |
| CHLORHEXIDINE GLUCONATE | 0.12% | solution · dental | BAJAJ | Prescription | 14 Nov 2000 |
| CHLORHEXIDINE GLUCONATE | 0.12% | solution · dental | CHARTWELL RX | Prescription | 3 Mar 2004 |
| CHLORHEXIDINE GLUCONATE | 2% | cloth · topical | SAGE PRODS | Over-the-counter | 25 Apr 2005 |
| CHLORHEXIDINE GLUCONATE | 0.12% | solution · dental | PHARMOBEDIENT | Prescription | 18 Jun 2009 |
| PERIOGARD | 0.12% | solution · dental | COLGATE-PALMOLIVE CO | Prescription | 28 Jan 2016 |
| READYPREP CHG | 2% | cloth · topical | MEDLINE INDUSTRIES | Over-the-counter | 20 Nov 2018 |
| HIBICLENS | 4% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | sponge · topical | MOLNLYCKE HLTH | Discontinued | 27 Aug 1981 |
| EXIDINE | 2.5% | solution · topical | XTTRIUM | Discontinued | 17 Dec 1985 |
| STERI-STAT | 4% | solution · topical | MATRIX MEDCL | Discontinued | 24 Jul 1986 |
| BRIAN CARE | 4% | solution · topical | SOAPCO | Discontinued | 17 Dec 1987 |
| PHARMASEAL SCRUB CARE | 4% | sponge · topical | CAREFUSION 2200 | Discontinued | 2 Dec 1988 |
| MICRODERM | 4% | sponge · topical | J AND J | Discontinued | 28 Feb 1991 |
8 more — full table
Canada Canada — marketed products (Health Canada)
| Brand | DIN | Strength | Form · route | Company |
|---|---|---|---|---|
| ANTISEPTIC BODY CLEANSER | 02245741 | 2 % | WIPE · TOPICAL | SAGE PRODUCTS LLC |
| BAXEDIN LIQ 20% | 00658413 | 20 % | SOLUTION · TOPICAL | OMEGA LABORATORIES LIMITED |
| BAXEDIN PRE-OP | 01936441 | 0.5 % | SOLUTION · TOPICAL | OMEGA LABORATORIES LIMITED |
| CHLORHEXIDINE 4% ANTISEPTIC HAND WASH | 02295679 | 4 % / W/W | SOLUTION · TOPICAL (COMMERCIAL) | PARTNAR ANIMAL HEALTH INC. |
| CHLORHEXIDINE GLUCONATE SOLUTION 0.05% | 00832146 | 0.05 % | SOLUTION · TOPICAL | LABORATOIRE ATLAS INC |
| CHLORHEXIDINE SOLUTION | 02295253 | 2 % / W/W | SOLUTION · TOPICAL (COMMERCIAL) | PARTNAR ANIMAL HEALTH INC. |
| DEXIDIN 2 DETERGENT | 00832138 | 2 % / W/V | SOLUTION · TOPICAL | LABORATOIRE ATLAS INC |
| DEXIDIN 2 SOLUTION | 02238982 | 2 % | SOLUTION · TOPICAL | LABORATOIRE ATLAS INC |
| DEXIDIN 20 | 00832030 | 20 % / % | SOLUTION · TOPICAL | LABORATOIRE ATLAS INC |
| DEXIDIN LIQ 4% | 00832111 | 4 % / W/V | SOLUTION · TOPICAL | LABORATOIRE ATLAS INC |
| E-Z SCRUB 747 4% | 01939947 | 4 % / W/V | SPONGE · TOPICAL (HOSPITAL/HC FACILITIES) | BECTON DICKINSON |
| ENDURE 400 SCRUB-STAT 4 | 02239252 | 4 % | SOLUTION · TOPICAL | ECOLAB CO |
| ENDURE 420 CIDA-STAT | 02240416 | 2 % | SOLUTION · TOPICAL | ECOLAB CO |
| EURO-CHLORHEXIDINE | 02462842 | 0.12 % / W/V | MOUTHWASH · BUCCAL | EURO-PHARM INTERNATIONAL CANADA INC |
| HYGENIPAK 2% CHG FOAMING SKIN CLEANSER | 02267144 | 2 % / W/V | SOLUTION · TOPICAL (HOSPITAL/HC FACILITIES); TOPICAL (COMMERCIAL) | SC JOHNSON PROFESSIONAL CA INC |
| LORIS 2% CHG SOLUTION | 02358018 | 2 % / W/V | SOLUTION · TOPICAL (HOUSEHOLD) | LERNAPHARM (LORIS) INC. |
| LORIS 2% CHG WIPE/SERVIETTE | 02355965 | 2 % / W/V | WIPE · TOPICAL (HOUSEHOLD) | LERNAPHARM (LORIS) INC. |
| ORO CLEAR | 02291096 | 0.12 % | MOUTHWASH · BUCCAL | GERMIPHENE CORPORATION |
| ORO-CLENSE | 02209055 | 0.12 % | MOUTHWASH · BUCCAL | GERMIPHENE CORPORATION |
| PERIDEX ORAL RINSE | 02237452 | 0.12 % / W/V | MOUTHWASH · BUCCAL | SOLVENTUM CANADA LIMITED |
| PERIOGARD ALCOHOL FREE | 02405091 | 0.12 % / W/W | SOLUTION · BUCCAL | COLGATE-PALMOLIVE CANADA INC |
| PMS-CHLORHEXIDINE | 02240433 | 0.12 % | MOUTHWASH · BUCCAL | PHARMASCIENCE INC |
| PMS-CHLORHEXIDINE WITHOUT ALCOHOL | 02493160 | 0.12 % | MOUTHWASH · BUCCAL | PHARMASCIENCE INC |
| PREVORA STAGE 1 | 02046245 | 10 % | SOLUTION; KIT · DENTAL | CHX TECHNOLOGIES INC |
| PURELL ANTIMICROBIAL FOAM HANDWASH 2% CHG | 02526697 | 2 % / W/W | SOLUTION · TOPICAL (COMMERCIAL) | GOJO CANADA INC |
3 more — full table
Prices — United States and England
| Source | Product as listed | Price | Unit / pack | Date |
|---|---|---|---|---|
| US NADAC | CHLORHEXIDINE 0.12% RINSE | $0.00734 | per ML | 23 Sep 2026 |
| US NADAC | CHLORHEXIDINE 4% LIQUID | $0.03992 | per ML | 23 Sep 2026 |
| US NADAC | CHLORHEXIDINE 4% LIQUID | $0.02849 | per ML | 23 Sep 2026 |
| US NADAC | CHLORHEXIDINE 4% LIQUID | $0.01776 | per ML | 23 Sep 2026 |
| NHS Drug Tariff | Chlorhexidine 1% dental gel sugar free | £3.24 | 50 gram | 1 Oct 2026 |
| NHS Drug Tariff | Chlorhexidine gluconate 0.2% mouthwash | £2.70 | 300 ml | 1 Oct 2026 |
| NHS Drug Tariff | Chlorhexidine gluconate 0.25% cream | £2.54 | 30 gram | 1 Oct 2026 |
| NHS Drug Tariff | Chlorhexidine gluconate 1% cream | £24.20 | 250 ml | 1 Oct 2026 |
| NHS Drug Tariff | Chlorhexidine gluconate 1% solution | £38.56 | 150 ml | 1 Oct 2026 |
| NHS Drug Tariff | Chlorhexidine gluconate 4% solution | £3.26 | 125 ml | 1 Oct 2026 |
| NHS Drug Tariff | Chlorhexidine gluconate 4% solution | £5.26 | 250 ml | 1 Oct 2026 |
| NHS Drug Tariff | Chlorhexidine gluconate 4% solution | £8.28 | 500 ml | 1 Oct 2026 |
| NHS Drug Tariff | Chlorhexidine gluconate 4% solution | £49.95 | 5000 ml | 1 Oct 2026 |
| NHS Drug Tariff | Chlorhexidine hydrochloride 0.5% cream | £2.86 | 30 gram | 1 Oct 2026 |
NADAC: average price US retail pharmacies pay to buy the medicine. NHS Drug Tariff Part VIIIA: basic price reimbursed to pharmacies in England and Wales.
WHO WHO Model List of Essential Medicines (2025)
- 22.7. Medicines administered to the neonate [c] · core
Omphalitis of newborn
Local > Topical > Solution: 7.1% chlorhexidine digluconate (delivering 4% chlorhexidine) (EMLc) | Local > Topical > Gel: 7.1% chlorhexidine digluconate (delivering 4% chlorhexidine) (EMLc) - 15.1. Antiseptics · core
Chlorhexidine
Local > Topical > Solution: 5% (digluconate) for dilution
Safety signals and safety-related labeling changes
- US FDA 20 Jan 2023 SOLUPREP — safety-related labeling change
Labeling sections changed: Adverse Reactions - US FDA 11 May 2018 BIOSCRUB — safety-related labeling change
Labeling sections changed: Warnings and Precautions - US FDA 19 Apr 2018 HIBISTAT — safety-related labeling change
Labeling sections changed: Warnings and Precautions - US FDA 10 Jan 2018 CHG SCRUB — safety-related labeling change
Labeling sections changed: Warnings and Precautions - US FDA 10 Jan 2018 CIDA-STAT — safety-related labeling change
Labeling sections changed: Warnings and Precautions - US FDA 20 Nov 2017 DYNA-HEX — safety-related labeling change
Labeling sections changed: Warnings and Precautions - US FDA 17 Oct 2017 HIBICLENS — safety-related labeling change
Labeling sections changed: Warnings and Precautions - US FDA 15 Sep 2017 EXIDINE — safety-related labeling change
Labeling sections changed: Warnings and Precautions - US FDA 14 Sep 2017 EXIDINE — safety-related labeling change
Labeling sections changed: Warnings and Precautions - US FDA 14 Sep 2017 EXIDINE — safety-related labeling change
Labeling sections changed: Warnings and Precautions - US FDA 12 Sep 2017 CHLORAPREP ONE-STEP SEPP — safety-related labeling change
Labeling sections changed: Warnings and Precautions - US FDA 12 Sep 2017 CHLORAPREP SINGLE SWABSTICK — safety-related labeling change
Labeling sections changed: Warnings and Precautions - US FDA 12 Sep 2017 CHLORAPREP TRIPLE SWABSTICK — safety-related labeling change
Labeling sections changed: Warnings and Precautions - US FDA 7 Sep 2017 PREVANTICS MAXI SWABSTICK — safety-related labeling change
Labeling sections changed: Warnings and Precautions - US FDA 7 Sep 2017 PREVANTICS SWAB — safety-related labeling change
Labeling sections changed: Warnings and Precautions
Combinations containing Chlorhexidine
Values as published by each source: SFDA human drug list (4-2026, as published by the Council of Health Insurance; indications from the CHI Daman Drug Formulary), Drugs@FDA, EMA medicines data, Health Canada Drug Product Database (Open Government Licence – Canada), CMS NADAC, NHS Drug Tariff Part VIIIA (NHSBSA Copyright, Open Government Licence v3.0), WHO Model List of Essential Medicines (CC BY 3.0 IGO; regrouped by active substance, not created by WHO), EMA PRAC, US FDA safety-related labeling changes and MHRA Drug Safety Update (Open Government Licence v3.0). Sources and reuse. Not a substitute for the official registers or the product information.