Is Chlorothiazide registered with the SFDA?

The SFDA human drug list (edition 4-2026, as published by the Council of Health Insurance) lists 5 valid registrations of Chlorothiazide, including Chlorothiazide BOS (500 mg, powder for solution for injection, SAR 461.90); MICARDIS PLUS (80,12.5 mg,mg, Tablet, SAR 65.05); NIZORTAN PLUS (40,12.5 mg,mg, Tablet, SAR 53.30); NIZORTAN PLUS (80,12.5 mg,mg, Tablet, SAR 53.30); NIZORTAN PLUS (80,25 mg,mg, Tablet, SAR 53.30).

Is Chlorothiazide approved by the US FDA?

Drugs@FDA lists 21 application product lines for Chlorothiazide, including CHLOROTHIAZIDE SODIUM (Prescription); CHLOROTHIAZIDE SODIUM (Prescription); CHLOROTHIAZIDE SODIUM (Prescription); CHLOROTHIAZIDE SODIUM (Prescription); CHLOROTHIAZIDE SODIUM (Prescription).

Is Chlorothiazide on the WHO Model List of Essential Medicines?

Yes — 12.3. Antihypertensive medicines (core list): Therapeutic equivalent to hydrochlorothiazide for Essential hypertension.

Active substance

Chlorothiazide

SFDA 7
US FDA 21
WHO EML 2

Open in the medicines table

SFDA Saudi Arabia — SFDA human drug list

Trade name	Strength	Form · route	Pack	Public price	Type	Company	Status
Chlorothiazide BOS	500 mg	powder for solution for injection · Intravenous use	1 Vial	SAR 461.90	Generic · Prescription	Boston Oncology Arabia	Valid
MICARDIS PLUS	80,12.5 mg,mg	Tablet · Oral use	28 Blister	SAR 65.05	NCE · Prescription	BOEHRINGER INGELHEIM	Valid
NIZORTAN PLUS	40,12.5 mg,mg	Tablet · Oral use	28 Blister	SAR 53.30	Generic · Prescription	Tabuk Pharmaceutical Manufacturing Company	Valid
NIZORTAN PLUS	80,12.5 mg,mg	Tablet · Oral use	28 Blister	SAR 53.30	Generic · Prescription	Tabuk Pharmaceutical Manufacturing Company	Valid
NIZORTAN PLUS	80,25 mg,mg	Tablet · Oral use	28 Blister	SAR 53.30	Generic · Prescription	Tabuk Pharmaceutical Manufacturing Company	Valid
LISART PLUS 40 MG/12.5 MG TABLET	40 , 12.5 mg	Tablet · Oral use	28 Blister	SAR 59.20	Generic · Prescription	RIYADH PHARMA	Withdrawn by MAH · Not Marketed
LISART PLUS 80 MG/12.5 MG TABLET	80 , 12.5 mg	Tablet · Oral use	28 Blister	SAR 59.20	Generic · Prescription	RIYADH PHARMA	Withdrawn by MAH · Not Marketed

Indications — CHI Daman Drug Formulary

HYPERTENSION

US FDA United States — FDA approvals (Drugs@FDA)

Product	Strength	Form · route	Applicant	Status	First approved
CHLOROTHIAZIDE SODIUM	EQ 500MG BASE/VIAL	injectable · injection	FRESENIUS KABI USA	Prescription	16 Oct 2009
CHLOROTHIAZIDE SODIUM	EQ 500MG BASE/VIAL	injectable · injection	SUN PHARM	Prescription	26 Jul 2011
CHLOROTHIAZIDE SODIUM	EQ 500MG BASE/VIAL	injectable · injection	AM REGENT	Prescription	22 Apr 2013
CHLOROTHIAZIDE SODIUM	EQ 500MG BASE/VIAL	injectable · injection	SAGENT PHARMS INC	Prescription	29 May 2015
CHLOROTHIAZIDE SODIUM	EQ 500MG BASE/VIAL	injectable · injection	GLAND	Prescription	3 Oct 2024
DIURIL	500MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons; 250MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	tablet · oral	RISING	Discontinued	4 Sep 1958
DIURIL	EQ 500MG BASE/VIAL Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	injectable · injection	RISING	Discontinued	4 Sep 1958
DIURIL	250MG/5ML	suspension · oral	SALIX PHARMS	Discontinued	6 Oct 1961
CHLOROTHIAZIDE	500MG; 250MG	tablet · oral	PHARMOBEDIENT	Discontinued	17 Jul 1975
CHLOROTHIAZIDE	250MG	tablet · oral	WATSON LABS	Discontinued	4 Nov 1977
CHLOROTHIAZIDE	250MG	tablet · oral	ABC HOLDING	Discontinued	8 Mar 1978
CHLOROTHIAZIDE	250MG	tablet · oral	SANDOZ	Discontinued	1 Apr 1981
CHLOROTHIAZIDE	250MG	tablet · oral	HIKMA INTL PHARMS	Discontinued	14 Jul 1982
CHLOROTHIAZIDE	500MG	tablet · oral	HIKMA INTL PHARMS	Discontinued	14 Jul 1982
CHLOROTHIAZIDE	250MG	tablet · oral	WATSON LABS	Discontinued	15 Aug 1983
CHLOROTHIAZIDE SODIUM	EQ 500MG BASE/VIAL	injectable · injection	RK PHARMA	Discontinued	18 Jun 2014
CHLOROTHIAZIDE	500MG	tablet · oral	WATSON LABS	Discontinued
CHLOROTHIAZIDE	250MG	tablet · oral	WATSON LABS	Discontinued
CHLOROTHIAZIDE	500MG	tablet · oral	WATSON LABS	Discontinued
CHLOROTHIAZIDE	500MG	tablet · oral	LEDERLE	Discontinued
CHLOROTHIAZIDE	250MG	tablet · oral	LEDERLE	Discontinued

WHO WHO Model List of Essential Medicines (2025)

12.3. Antihypertensive medicines · core
Therapeutic equivalent to hydrochlorothiazide for Essential hypertension
12.4. Medicines used in heart failure · core
Therapeutic equivalent to hydrochlorothiazide for Heart failure

Values as published by each source: SFDA human drug list (4-2026, as published by the Council of Health Insurance; indications from the CHI Daman Drug Formulary), Drugs@FDA, EMA medicines data, Health Canada Drug Product Database (Open Government Licence – Canada), CMS NADAC, NHS Drug Tariff Part VIIIA (NHSBSA Copyright, Open Government Licence v3.0), WHO Model List of Essential Medicines (CC BY 3.0 IGO; regrouped by active substance, not created by WHO), EMA PRAC, US FDA safety-related labeling changes and MHRA Drug Safety Update (Open Government Licence v3.0). Sources and reuse. Not a substitute for the official registers or the product information.