Active substance
Chlortalidone
- SFDA 2
- US FDA 65
- Health Canada 7
- US price lines 4
- NHS prices 2
- WHO EML 2
- Safety 4
SFDA Saudi Arabia — SFDA human drug list
| Trade name | Strength | Form · route | Pack | Public price | Type | Company | Status |
|---|---|---|---|---|---|---|---|
| HYGROTON 50MG TABLETS | 50 mg | Tablet · Oral use | 20 Blister | SAR 17.90 | NCE · Prescription | AMDIPHARMA | Withdrawn by MAH · Not Marketed |
| HYGROTON 50MG TABLETS | 50 mg | Tablet · Oral use | 20 Blister | SAR 17.90 | NCE · Prescription | NOVARTIS | Withdrawn by MAH · Not Marketed |
US FDA United States — FDA approvals (Drugs@FDA)
| Product | Strength | Form · route | Applicant | Status | First approved |
|---|---|---|---|---|---|
| CHLORTHALIDONE | 50MG; 25MG | tablet · oral | MYLAN | Prescription | 26 Feb 1981 |
| CHLORTHALIDONE | 50MG; 25MG | tablet · oral | SUN PHARM INDUSTRIES | Prescription | 21 Jul 1986 |
| THALITONE | 15MG | tablet · oral | CASPER PHARMA LLC | Prescription | 20 Dec 1988 |
| CHLORTHALIDONE | 25MG; 50MG | tablet · oral | INGENUS PHARMS LLC | Prescription | 30 Mar 2017 |
| CHLORTHALIDONE | 25MG; 50MG | tablet · oral | UMEDICA | Prescription | 24 May 2018 |
| CHLORTHALIDONE | 25MG; 50MG | tablet · oral | APPCO | Prescription | 12 Oct 2018 |
| CHLORTHALIDONE | 25MG; 50MG | tablet · oral | CHARTWELL RX | Prescription | 26 Feb 2019 |
| CHLORTHALIDONE | 25MG; 50MG | tablet · oral | ZYDUS PHARMS | Prescription | 10 May 2019 |
| CHLORTHALIDONE | 25MG; 50MG | tablet · oral | AMNEAL PHARMS CO | Prescription | 1 Jul 2019 |
| CHLORTHALIDONE | 25MG; 50MG | tablet · oral | UNICHEM | Prescription | 6 Aug 2019 |
| CHLORTHALIDONE | 25MG; 50MG | tablet · oral | ALKEM LABS LTD | Prescription | 11 Feb 2020 |
| CHLORTHALIDONE | 25MG; 50MG | tablet · oral | AJANTA PHARMA LTD | Prescription | 27 Nov 2020 |
| CHLORTHALIDONE | 25MG; 50MG | tablet · oral | ADAPTIS | Prescription | 9 Feb 2022 |
| CHLORTHALIDONE | 50MG | tablet · oral | PHARMOBEDIENT | Prescription | 24 Feb 2022 |
| CHLORTHALIDONE | 25MG | tablet · oral | PHARMOBEDIENT | Prescription | 24 Feb 2022 |
| CHLORTHALIDONE | 25MG; 50MG | tablet · oral | MANKIND PHARMA | Prescription | 4 Aug 2022 |
| CHLORTHALIDONE | 25MG; 50MG | tablet · oral | ALEMBIC | Prescription | 26 Aug 2022 |
| CHLORTHALIDONE | 25MG; 50MG | tablet · oral | IPCA LABS LTD | Prescription | 12 Nov 2024 |
| HEMICLOR | 12.5MG | tablet · oral | PRM PHARMA | Prescription | 17 Mar 2025 |
| CHLORTHALIDONE | 25MG; 50MG | tablet · oral | MACLEODS PHARMS | Prescription | 1 Jul 2026 |
| HYGROTON | 50MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**; 25MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | tablet · oral | SANOFI AVENTIS US | Discontinued | 7 Apr 1960 |
| CHLORTHALIDONE | 25MG | tablet · oral | MUTUAL PHARM | Discontinued | 5 Mar 1981 |
| CHLORTHALIDONE | 50MG | tablet · oral | MUTUAL PHARM | Discontinued | 5 Mar 1981 |
| CHLORTHALIDONE | 25MG | tablet · oral | ABBOTT | Discontinued | 6 Mar 1981 |
| CHLORTHALIDONE | 50MG | tablet · oral | ABBOTT | Discontinued | 6 Mar 1981 |
40 more — full table
Canada Canada — marketed products (Health Canada)
| Brand | DIN | Strength | Form · route | Company |
|---|---|---|---|---|
| APO-CHLORTHALIDONE | 00360279 | 50 MG | TABLET · ORAL | APOTEX INC |
| JAMP CHLORTHALIDONE | 02523795 | 12.5 MG | TABLET · ORAL | JAMP PHARMA CORPORATION |
| JAMP CHLORTHALIDONE | 02523809 | 25 MG | TABLET · ORAL | JAMP PHARMA CORPORATION |
| JAMP CHLORTHALIDONE | 02523817 | 50 MG | TABLET · ORAL | JAMP PHARMA CORPORATION |
| MINT-CHLORTHALIDONE | 02557126 | 12.5 MG | TABLET · ORAL | MINT PHARMACEUTICALS INC |
| MINT-CHLORTHALIDONE | 02557134 | 25 MG | TABLET · ORAL | MINT PHARMACEUTICALS INC |
| MINT-CHLORTHALIDONE | 02557142 | 50 MG | TABLET · ORAL | MINT PHARMACEUTICALS INC |
Prices — United States and England
| Source | Product as listed | Price | Unit / pack | Date |
|---|---|---|---|---|
| US NADAC | CHLORTHALIDONE 25 MG TABLET | $0.07433 | per EA | 23 Sep 2026 |
| US NADAC | CHLORTHALIDONE 50 MG TABLET | $0.12175 | per EA | 23 Sep 2026 |
| US NADAC | HEMICLOR 12.5 MG TABLET | $0.95713 | per EA | 23 Sep 2026 |
| US NADAC | THALITONE 15 MG TABLET | $3.54226 | per EA | 23 Sep 2026 |
| NHS Drug Tariff | Chlortalidone 12.5mg tablets | £42.00 | 30 tablet | 1 Oct 2026 |
| NHS Drug Tariff | Chlortalidone 50mg tablets | £16.57 | 30 tablet | 1 Oct 2026 |
NADAC: average price US retail pharmacies pay to buy the medicine. NHS Drug Tariff Part VIIIA: basic price reimbursed to pharmacies in England and Wales.
WHO WHO Model List of Essential Medicines (2025)
- 12.3. Antihypertensive medicines · core
Therapeutic equivalent to hydrochlorothiazide for Essential hypertension - 12.4. Medicines used in heart failure · core
Therapeutic equivalent to hydrochlorothiazide for Heart failure
Safety signals and safety-related labeling changes
- US FDA 22 Dec 2023 TENORETIC 100 — safety-related labeling change
Labeling sections changed: Warnings and Precautions; Patient Counseling Information / Patient Information / Medication Guide - US FDA 22 Dec 2023 TENORETIC 50 — safety-related labeling change
Labeling sections changed: Warnings and Precautions; Patient Counseling Information / Patient Information / Medication Guide - US FDA 9 Mar 2020 EDARBYCLOR — safety-related labeling change
Labeling sections changed: Contraindications; Warnings and Precautions; Adverse Reactions; Use in Specific Populations - US FDA 17 Sep 2019 THALITONE — safety-related labeling change
Labeling sections changed: Contraindications; Warnings and Precautions; Use in Specific Populations; Patient Counseling Information / Patient Information / Medication Guide
Combinations containing Chlortalidone
Values as published by each source: SFDA human drug list (4-2026, as published by the Council of Health Insurance; indications from the CHI Daman Drug Formulary), Drugs@FDA, EMA medicines data, Health Canada Drug Product Database (Open Government Licence – Canada), CMS NADAC, NHS Drug Tariff Part VIIIA (NHSBSA Copyright, Open Government Licence v3.0), WHO Model List of Essential Medicines (CC BY 3.0 IGO; regrouped by active substance, not created by WHO), EMA PRAC, US FDA safety-related labeling changes and MHRA Drug Safety Update (Open Government Licence v3.0). Sources and reuse. Not a substitute for the official registers or the product information.