Active substance
Clomipramine
- SFDA 2
- US FDA 22
- Health Canada 5
- US price lines 3
- NHS prices 3
- WHO EML 1
- Safety 4
SFDA Saudi Arabia — SFDA human drug list
| Trade name | Strength | Form · route | Pack | Public price | Type | Company | Status |
|---|---|---|---|---|---|---|---|
| ANAFRANIL TAB 10MG | 10 mg | Coated tablet · Oral use | 30 Blister | SAR 17.90 | NCE · Prescription | TEOFARMA S.R.L | Valid |
| ANAFRANIL TABLETS 25 MG | 25 mg | Coated tablet · Oral use | 30 Blister | SAR 21.40 | NCE · Prescription | TEOFARMA S.R.L | Valid |
Indications — CHI Daman Drug Formulary
ANXIETY DISORDERS; DEPRESSION; NARCOLEPSY AND CATAPLEXY
US FDA United States — FDA approvals (Drugs@FDA)
| Product | Strength | Form · route | Applicant | Status | First approved |
|---|---|---|---|---|---|
| ANAFRANIL | 25MG; 50MG; 75MG | capsule · oral | SPECGX LLC | Prescription | 29 Dec 1989 |
| CLOMIPRAMINE HYDROCHLORIDE | 25MG; 50MG; 75MG | capsule · oral | CHARTWELL RX | Prescription | 29 Mar 1996 |
| CLOMIPRAMINE HYDROCHLORIDE | 25MG; 50MG; 75MG | capsule · oral | TARO | Prescription | 31 Dec 1996 |
| CLOMIPRAMINE HYDROCHLORIDE | 25MG; 50MG; 75MG | capsule · oral | SANDOZ | Prescription | 25 Jun 1997 |
| CLOMIPRAMINE HYDROCHLORIDE | 25MG; 50MG; 75MG | capsule · oral | ZYDUS PHARMS | Prescription | 27 Dec 2017 |
| CLOMIPRAMINE HYDROCHLORIDE | 25MG; 50MG; 75MG | capsule · oral | LUPIN | Prescription | 21 Nov 2018 |
| CLOMIPRAMINE HYDROCHLORIDE | 25MG; 50MG; 75MG | capsule · oral | MANKIND PHARMA | Prescription | 8 Apr 2019 |
| CLOMIPRAMINE HYDROCHLORIDE | 25MG; 50MG; 75MG | capsule · oral | JUBILANT CADISTA | Prescription | 21 Oct 2019 |
| CLOMIPRAMINE HYDROCHLORIDE | 25MG; 50MG; 75MG | capsule · oral | LEADING | Prescription | 7 Feb 2020 |
| CLOMIPRAMINE HYDROCHLORIDE | 25MG; 50MG; 75MG | capsule · oral | MICRO LABS | Prescription | 22 Jun 2020 |
| CLOMIPRAMINE HYDROCHLORIDE | 25MG; 50MG; 75MG | capsule · oral | UNIQUE | Prescription | 7 Aug 2020 |
| CLOMIPRAMINE HYDROCHLORIDE | 25MG; 50MG; 75MG | capsule · oral | ALEMBIC | Prescription | 4 Aug 2021 |
| CLOMIPRAMINE HYDROCHLORIDE | 25MG; 50MG; 75MG | capsule · oral | AUROBINDO PHARMA | Prescription | 20 Mar 2023 |
| CLOMIPRAMINE HYDROCHLORIDE | 25MG; 50MG; 75MG | capsule · oral | WATSON LABS | Discontinued | 27 Nov 1996 |
| CLOMIPRAMINE HYDROCHLORIDE | 25MG; 50MG; 75MG | capsule · oral | TEVA | Discontinued | 4 Apr 1997 |
| CLOMIPRAMINE HYDROCHLORIDE | 25MG; 50MG; 75MG | capsule · oral | TEVA | Discontinued | 26 Aug 1997 |
| CLOMIPRAMINE HYDROCHLORIDE | 25MG; 50MG; 75MG | capsule · oral | PHARMOBEDIENT | Discontinued | 30 Apr 1998 |
| CLOMIPRAMINE HYDROCHLORIDE | 25MG; 50MG; 75MG | capsule · oral | WATSON LABS | Discontinued | 30 Sep 1998 |
| CLOMIPRAMINE HYDROCHLORIDE | 25MG; 50MG; 75MG | capsule · oral | AMNEAL PHARMS CO | Discontinued | 31 Oct 2018 |
| CLOMIPRAMINE HYDROCHLORIDE | 25MG; 50MG; 75MG | capsule · oral | TP ANDA HOLDINGS | Discontinued | 3 Apr 2020 |
| CLOMIPRAMINE HYDROCHLORIDE | 25MG; 50MG; 75MG | capsule · oral | RK PHARMA | Discontinued | 22 Jun 2020 |
| CLOMIPRAMINE HYDROCHLORIDE | 25MG; 50MG; 75MG | capsule · oral | AJANTA PHARMA LTD | Discontinued | 2 Oct 2020 |
Canada Canada — marketed products (Health Canada)
| Brand | DIN | Strength | Form · route | Company |
|---|---|---|---|---|
| ANAFRANIL | 00324019 | 25 MG | TABLET · ORAL | APOTEX INC |
| ANAFRANIL | 00330566 | 10 MG | TABLET · ORAL | APOTEX INC |
| ANAFRANIL | 00402591 | 50 MG | TABLET · ORAL | APOTEX INC |
| TARO-CLOMIPRAMINE | 02497506 | 25 MG | CAPSULE · ORAL | TARO PHARMACEUTICALS INC |
| TARO-CLOMIPRAMINE | 02497514 | 50 MG | CAPSULE · ORAL | TARO PHARMACEUTICALS INC |
Prices — United States and England
| Source | Product as listed | Price | Unit / pack | Date |
|---|---|---|---|---|
| US NADAC | CLOMIPRAMINE 25 MG CAPSULE | $0.18882 | per EA | 23 Sep 2026 |
| US NADAC | CLOMIPRAMINE 50 MG CAPSULE | $0.25815 | per EA | 23 Sep 2026 |
| US NADAC | CLOMIPRAMINE 75 MG CAPSULE | $0.2501 | per EA | 23 Sep 2026 |
| NHS Drug Tariff | Clomipramine 10mg capsules | £3.54 | 28 capsule | 1 Oct 2026 |
| NHS Drug Tariff | Clomipramine 25mg capsules | £4.95 | 28 capsule | 1 Oct 2026 |
| NHS Drug Tariff | Clomipramine 50mg capsules | £8.90 | 28 capsule | 1 Oct 2026 |
NADAC: average price US retail pharmacies pay to buy the medicine. NHS Drug Tariff Part VIIIA: basic price reimbursed to pharmacies in England and Wales.
WHO WHO Model List of Essential Medicines (2025)
- 24.4. Medicines for obsessive compulsive disorders · core
Obsessive-compulsive disorder
Oral > Solid: 10 mg (hydrochloride); 25 mg (hydrochloride)
Safety signals and safety-related labeling changes
- EMA PRAC 16 May 2019 PRAC signal: Persistent sexual dysfunction after drug withdrawal
Action for MAH: update of the product information: Yes - US FDA 10 May 2019 ANAFRANIL — safety-related labeling change
Labeling sections changed: Warnings and Precautions; Adverse Reactions; Patient Counseling Information / Patient Information / Medication Guide - EMA PRAC 31 Oct 2018 PRAC signal: Persistent sexual dysfunction after drug withdrawal
Action for MAH: update of the product information: No - EMA PRAC 6 Sep 2018 PRAC signal: Persistent sexual dysfunction after drug withdrawal
Action for MAH: update of the product information: No
Values as published by each source: SFDA human drug list (4-2026, as published by the Council of Health Insurance; indications from the CHI Daman Drug Formulary), Drugs@FDA, EMA medicines data, Health Canada Drug Product Database (Open Government Licence – Canada), CMS NADAC, NHS Drug Tariff Part VIIIA (NHSBSA Copyright, Open Government Licence v3.0), WHO Model List of Essential Medicines (CC BY 3.0 IGO; regrouped by active substance, not created by WHO), EMA PRAC, US FDA safety-related labeling changes and MHRA Drug Safety Update (Open Government Licence v3.0). Sources and reuse. Not a substitute for the official registers or the product information.