Active substance
Clonazepam
- SFDA 5
- US FDA 20
- Health Canada 8
- US price lines 14
- NHS prices 5
- Safety 3
SFDA Saudi Arabia — SFDA human drug list
| Trade name | Strength | Form · route | Pack | Public price | Type | Company | Status |
|---|---|---|---|---|---|---|---|
| RIVOTRIL 2.5MG-ML ORAL SOLUTION | 2.5 mg/ml | Oral drops, solution · Oral use | 1 Bottle | SAR 12.10 | NCE · Prescription | ROCHE | Valid |
| RIVOTRIL TAB 0.5MG | 0.5 mg | Tablet · Oral use | 50 Blister | SAR 15.30 | NCE · Prescription | ROCHE | Valid |
| RIVOTRIL TAB 2 MG | 2 mg | Tablet · Oral use | 30 Bottle | SAR 19.20 | NCE · Prescription | ROCHE | Valid |
| RIVOTRIL AMP 1MG+SOLV 1ML | 1 mg | Injection · Intravenous use | 25 Ampoule | SAR 91.05 | NCE · Prescription | ROCHE | Withdrawn by MAH · Not Marketed |
| RIVOTRIL TAB 2 MG | 2 mg | Tablet · Oral use | 100 Blister | SAR 41.85 | NCE · Prescription | ROCHE | Withdrawn by MAH · Not Marketed |
Indications — CHI Daman Drug Formulary
ABSENCE SEIZURES AND IDIOPATHIC GENERALIZED EPILEPSY; ACUTE MANIA; ANXIETY DISORDERS; BIPOLAR II DISORDER; HUNTINGTON'S DISEASE-TICS; JUVENILE MYOCLONIC SEIZURES; SCHIZOPHRENIA; SPASTICITY; VERTIGO - MENIERE'S DISEASE; VERTIGO - MOTION SICKNESS
US FDA United States — FDA approvals (Drugs@FDA)
| Product | Strength | Form · route | Applicant | Status | First approved |
|---|---|---|---|---|---|
| KLONOPIN | 0.5MG; 1MG; 2MG | tablet · oral | CHEPLAPHARM | Prescription | 4 Jun 1975 |
| CLONAZEPAM | 0.5MG; 1MG; 2MG | tablet · oral | TEVA | Prescription | 10 Sep 1996 |
| CLONAZEPAM | 0.5MG; 1MG; 2MG | tablet · oral | ACTAVIS ELIZABETH | Prescription | 31 Oct 1996 |
| CLONAZEPAM | 0.5MG; 1MG; 2MG | tablet · oral | SANDOZ | Prescription | 29 Aug 1997 |
| CLONAZEPAM | 0.5MG; 1MG; 2MG | tablet · oral | CHARTWELL RX | Prescription | 30 Sep 1997 |
| CLONAZEPAM | 0.5MG; 1MG; 2MG | tablet · oral | AUROBINDO PHARMA USA | Prescription | 5 Oct 1998 |
| CLONAZEPAM | 0.5MG; 1MG; 2MG; 0.25MG | tablet · oral | RUBICON RESEARCH | Prescription | 6 Oct 2000 |
| CLONAZEPAM | 0.5MG; 1MG; 2MG | tablet · oral | ACCORD HLTHCARE | Prescription | 2 May 2005 |
| CLONAZEPAM | 0.125MG; 0.25MG; 0.5MG; 1MG; 2MG | tablet, orally disintegrating · oral | PH HEALTH | Prescription | 3 Aug 2005 |
| CLONAZEPAM | 0.125MG; 0.25MG; 0.5MG; 1MG; 2MG | tablet, orally disintegrating · oral | BARR | Prescription | 10 Aug 2005 |
| CLONAZEPAM | 0.5MG; 1MG; 2MG | tablet · oral | PRINSTON INC | Prescription | 28 Jun 2006 |
| CLONAZEPAM | 0.125MG; 0.25MG; 0.5MG; 1MG; 2MG | tablet, orally disintegrating · oral | ALEMBIC | Prescription | 28 Jun 2019 |
| CLONAZEPAM | 0.125MG; 0.25MG; 0.5MG; 1MG; 2MG | tablet, orally disintegrating · oral | RUBICON RESEARCH | Prescription | 21 May 2026 |
| KLONOPIN | 0.125MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**; 0.25MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | tablet · oral | CHEPLAPHARM | Discontinued | 4 Jun 1975 |
| CLONAZEPAM | 0.5MG; 1MG; 2MG | tablet · oral | QUAGEN | Discontinued | 30 Oct 1997 |
| KLONOPIN RAPIDLY DISINTEGRATING | 0.125MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**; 0.25MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**; 0.5MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**; 1MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**; 2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | tablet, orally disintegrating · oral | ROCHE | Discontinued | 23 Dec 1997 |
| CLONAZEPAM | 0.5MG; 1MG; 2MG | tablet · oral | WATSON LABS | Discontinued | 30 Dec 1997 |
| CLONAZEPAM | 0.5MG; 1MG; 2MG | tablet · oral | TEVA | Discontinued | 4 Aug 1998 |
| CLONAZEPAM | 0.5MG; 1MG; 2MG | tablet · oral | SUN PHARM INDS INC | Discontinued | 27 Apr 2001 |
| CLONAZEPAM | 0.125MG; 0.25MG; 0.5MG; 1MG; 2MG | tablet, orally disintegrating · oral | SUN PHARM INDS INC | Discontinued | 27 Aug 2014 |
Canada Canada — marketed products (Health Canada)
| Brand | DIN | Strength | Form · route | Company |
|---|---|---|---|---|
| APO-CLONAZEPAM | 02177889 | 0.5 MG | TABLET · ORAL | APOTEX INC |
| APO-CLONAZEPAM | 02177897 | 2 MG | TABLET · ORAL | APOTEX INC |
| PMS-CLONAZEPAM | 02048728 | 1 MG | TABLET · ORAL | PHARMASCIENCE INC |
| PMS-CLONAZEPAM | 02048736 | 2 MG | TABLET · ORAL | PHARMASCIENCE INC |
| PMS-CLONAZEPAM | 02179660 | 0.25 MG | TABLET · ORAL | PHARMASCIENCE INC |
| PMS-CLONAZEPAM-R | 02207818 | 0.5 MG | TABLET · ORAL | PHARMASCIENCE INC |
| RIVOTRIL | 00382825 | 0.5 MG | TABLET · ORAL | CHEPLAPHARM ARZNEIMITTEL GMBH |
| RIVOTRIL | 00382841 | 2 MG | TABLET · ORAL | CHEPLAPHARM ARZNEIMITTEL GMBH |
Prices — United States and England
| Source | Product as listed | Price | Unit / pack | Date |
|---|---|---|---|---|
| US NADAC | CLONAZEPAM 0.125 MG DIS TAB | $0.51985 | per EA | 23 Sep 2026 |
| US NADAC | CLONAZEPAM 0.125 MG ODT | $0.51985 | per EA | 23 Sep 2026 |
| US NADAC | CLONAZEPAM 0.25 MG ODT | $0.43849 | per EA | 23 Sep 2026 |
| US NADAC | CLONAZEPAM 0.5 MG DIS TABLET | $0.52314 | per EA | 23 Sep 2026 |
| US NADAC | CLONAZEPAM 0.5 MG ODT | $0.52314 | per EA | 23 Sep 2026 |
| US NADAC | CLONAZEPAM 0.5 MG TABLET | $0.01961 | per EA | 23 Sep 2026 |
| US NADAC | CLONAZEPAM 1 MG DIS TABLET | $0.56689 | per EA | 23 Sep 2026 |
| US NADAC | CLONAZEPAM 1 MG ODT | $0.56689 | per EA | 23 Sep 2026 |
| US NADAC | CLONAZEPAM 1 MG TABLET | $0.02438 | per EA | 23 Sep 2026 |
| US NADAC | CLONAZEPAM 2 MG ODT | $0.87917 | per EA | 23 Sep 2026 |
| US NADAC | CLONAZEPAM 2 MG TABLET | $0.04017 | per EA | 23 Sep 2026 |
| US NADAC | KLONOPIN 0.5 MG TABLET | $2.67886 | per EA | 23 Sep 2026 |
| NHS Drug Tariff | Clonazepam 1mg tablets | £41.95 | 100 tablet | 1 Oct 2026 |
| NHS Drug Tariff | Clonazepam 2mg tablets | £2.04 | 100 tablet | 1 Oct 2026 |
| NHS Drug Tariff | Clonazepam 2mg/5ml oral solution sugar free | £43.07 | 150 ml | 1 Oct 2026 |
| NHS Drug Tariff | Clonazepam 500microgram tablets | £1.69 | 100 tablet | 1 Oct 2026 |
| NHS Drug Tariff | Clonazepam 500micrograms/5ml oral solution sugar free | £31.72 | 150 ml | 1 Oct 2026 |
NADAC: average price US retail pharmacies pay to buy the medicine. NHS Drug Tariff Part VIIIA: basic price reimbursed to pharmacies in England and Wales.
Safety signals and safety-related labeling changes
- EMA PRAC 7 May 2026 PRAC signal: Miscarriage associated with in utero exposure to benzodiazepines (including fixed-dose combinations)
Action for MAH: update of the product information: No - US FDA 13 Jan 2023 KLONOPIN — safety-related labeling change
Labeling sections changed: Boxed Warning; Warnings and Precautions; Adverse Reactions; Drug Interactions; Use in Specific Populations; Patient Counseling Information / Patient Information / Medication Guide - US FDA 16 Dec 2016 KLONOPIN RAPIDLY DISINTEGRATING — safety-related labeling change
Labeling sections changed: Boxed Warning; Warnings and Precautions; Adverse Reactions; Drug Interactions; Patient Counseling Information / Patient Information / Medication Guide
Values as published by each source: SFDA human drug list (4-2026, as published by the Council of Health Insurance; indications from the CHI Daman Drug Formulary), Drugs@FDA, EMA medicines data, Health Canada Drug Product Database (Open Government Licence – Canada), CMS NADAC, NHS Drug Tariff Part VIIIA (NHSBSA Copyright, Open Government Licence v3.0), WHO Model List of Essential Medicines (CC BY 3.0 IGO; regrouped by active substance, not created by WHO), EMA PRAC, US FDA safety-related labeling changes and MHRA Drug Safety Update (Open Government Licence v3.0). Sources and reuse. Not a substitute for the official registers or the product information.