Active substance
Diltiazem
- SFDA 22
- US FDA 73
- Health Canada 75
- US price lines 25
- NHS prices 12
- Safety 4
SFDA Saudi Arabia — SFDA human drug list
| Trade name | Strength | Form · route | Pack | Public price | Type | Company | Status |
|---|---|---|---|---|---|---|---|
| DILZEM RETARD | 90 mg | Prolonged-release tablet · Oral use | 30 Blister | SAR 27.70 | Generic · Prescription | Pfizer Pharma GmbH | Valid |
| APO-DILTAZ 30MG TAB | 30 mg | Tablet · Oral use | 30 Blister | SAR 12.45 | Generic · Prescription | APOTEX | Withdrawn by MAH · Not Marketed |
| APO-DILTAZ 60MG TAB | 60 mg | Tablet · Oral use | 30 Blister | SAR 15.20 | Generic · Prescription | APOTEX | Withdrawn by MAH · Not Marketed |
| BI-TILDIEM 120MG TAB | 120 mg | Tablet · Oral use | 28 Blister | SAR 38.85 | Generic · Prescription | sanofi-aventis | Withdrawn by MAH · Not Marketed |
| BI-TILDIEM 90MG TAB | 90 mg | Tablet · Oral use | 28 Blister | SAR 26.35 | Generic · Prescription | sanofi-aventis | Withdrawn by MAH · Not Marketed |
| DILZEM | 60 mg | Tablet · Oral use | 30 Blister | SAR 19.75 | Generic · Prescription | PFIZER | Withdrawn by MAH · Not Marketed |
| MONO TILDIEM SR 200MG CAPS | 200 mg | Capsule · Oral use | 28 Blister | SAR 57.85 | Generic · Prescription | sanofi-aventis FRANCE | Withdrawn by MAH · Not Marketed |
| MONO TILDIEM SR 200MG CAPS | 200 mg | Capsule · Oral use | 28 Blister | SAR 57.85 | Generic · Prescription | sanofi-aventis | Withdrawn by MAH · Not Marketed |
| MONO TILDIEM SR 300MG CAPS | 300 mg | Prolonged-release capsule, hard · Oral use | 28 Blister | SAR 67.65 | Generic · Prescription | sanofi-aventis FRANCE | Withdrawn by MAH · Not Marketed |
| MONO TILDIEM SR 300MG CAPS | 300 mg | Prolonged-release capsule, hard · Oral use | 28 Blister | SAR 67.65 | Generic · Prescription | sanofi-aventis | Withdrawn by MAH · Not Marketed |
| NOVO-DILTAZEM 30MG TAB | 30 mg | Tablet · Oral use | 30 Blister | SAR 13.80 | Generic · Prescription | NOVOPHARM | Withdrawn by MAH · Not Marketed |
| NOVO-DILTAZEM 30MG TAB | 30 mg | Tablet · Oral use | 100 Blister | SAR 38.55 | Generic · Prescription | NOVOPHARM | Withdrawn by MAH · Not Marketed |
| NOVO-DILTAZEM 60MG TAB | 60 mg | Tablet · Oral use | 100 Blister | SAR 56.35 | Generic · Prescription | NOVOPHARM | Withdrawn by MAH · Not Marketed |
| NOVO-DILTAZEM 60MG TAB | 60 mg | Tablet · Oral use | 30 Blister | SAR 16.90 | Generic · Prescription | NOVOPHARM | Withdrawn by MAH · Not Marketed |
| RIAZEM 120MG CAP | 120 mg | Capsule · Oral use | 30 Blister | SAR 24.30 | Generic · Prescription | RIYADH PHARMA | Withdrawn by MAH · Not Marketed |
| RIAZEM 180MG CAP | 180 mg | Capsule · Oral use | 30 Blister | SAR 31.50 | Generic · Prescription | RIYADH PHARMA | Withdrawn by MAH · Not Marketed |
| RIAZEM 240MG CAP | 240 mg | Capsule · Oral use | 30 Blister | SAR 37.85 | Generic · Prescription | RIYADH PHARMA | Withdrawn by MAH · Not Marketed |
| RIAZEM 300MG CAP | 300 mg | Capsule · Oral use | 30 Blister | SAR 48.00 | Generic · Prescription | RIYADH PHARMA | Withdrawn by MAH · Not Marketed |
| RIAZEM 30MG F.C. TABLET | 30 mg | Film-coated tablet · Oral use | 30 Blister | SAR 8.75 | Generic · Prescription | RIYADH PHARMA | Withdrawn by MAH · Not Marketed |
| RIAZEM 60MG F.C TAB | 60 mg | Film-coated tablet · Oral use | 30 Blister | SAR 14.85 | Generic · Prescription | RIYADH PHARMA | Withdrawn by MAH · Not Marketed |
| TILDIEM 60MG TAB | 60 mg | Tablet · Oral use | 30 Blister | SAR 16.60 | NCE · Prescription | sanofi-aventis | Withdrawn by MAH · Not Marketed |
| TILDIEM 60MG TAB | 60 mg | Tablet · Oral use | 30 Blister | SAR 16.60 | NCE · Prescription | Sanofi Aventis France | Withdrawn by MAH · Not Marketed |
Indications — CHI Daman Drug Formulary
ANAL FISSURE; ARRHYTHMIA; CARDIOMYOPATHY; HYPERTENSION; PULMONARY ARTERIAL HYPERTENSION
US FDA United States — FDA approvals (Drugs@FDA)
| Product | Strength | Form · route | Applicant | Status | First approved |
|---|---|---|---|---|---|
| CARDIZEM | 30MG; 60MG; 90MG; 120MG | tablet · oral | BAUSCH | Prescription | 5 Nov 1982 |
| CARDIZEM CD | 120MG; 180MG; 240MG; 300MG; 360MG | capsule, extended release · oral | BAUSCH | Prescription | 27 Dec 1991 |
| DILTIAZEM HYDROCHLORIDE | 30MG; 60MG; 90MG; 120MG | tablet · oral | TEVA | Prescription | 31 May 1995 |
| TIAZAC | 120MG; 180MG; 240MG; 300MG; 360MG; 420MG | capsule, extended release · oral | BAUSCH | Prescription | 11 Sep 1995 |
| DILTIAZEM HYDROCHLORIDE | 5MG/ML | injectable · injection | SAGENT | Prescription | 28 Feb 1996 |
| DILTIAZEM HYDROCHLORIDE | 60MG; 90MG; 120MG | capsule, extended release · oral | MYLAN | Prescription | 2 May 1997 |
| DILTIAZEM HYDROCHLORIDE | 5MG/ML | injectable · injection | RISING | Prescription | 9 Apr 1998 |
| CARTIA XT | 180MG; 120MG; 240MG; 300MG | capsule, extended release · oral | ACTAVIS LABS FL INC | Prescription | 9 Jul 1998 |
| DILTIAZEM HYDROCHLORIDE | 240MG; 180MG; 120MG | capsule, extended release · oral | APOTEX | Prescription | 6 Aug 1998 |
| DILTIAZEM HYDROCHLORIDE | 120MG; 180MG; 240MG; 300MG | capsule, extended release · oral | PH HEALTH | Prescription | 20 Dec 1999 |
| DILTIAZEM HYDROCHLORIDE | 120MG; 180MG; 240MG; 300MG | capsule, extended release · oral | VALEANT PHARMS NORTH | Prescription | 23 Dec 1999 |
| DILTIAZEM HYDROCHLORIDE | 100MG/VIAL | injectable · injection | HOSPIRA | Prescription | 17 Dec 2002 |
| CARDIZEM LA | 120MG; 180MG; 240MG; 300MG; 360MG; 420MG | tablet, extended release · oral | BAUSCH | Prescription | 6 Feb 2003 |
| DILTIAZEM HYDROCHLORIDE | 5MG/ML | injectable · injection | HIKMA PHARMS | Prescription | 17 Dec 2008 |
| DILTIAZEM HYDROCHLORIDE | 420MG; 360MG; 300MG; 240MG; 180MG; 120MG | tablet, extended release · oral | ACTAVIS LABS FL INC | Prescription | 15 Mar 2010 |
| DILTIAZEM HYDROCHLORIDE | 50MG/10ML; 125MG/25ML | injectable · injection | HIKMA FARMACEUTICA | Prescription | 9 Aug 2012 |
| DILTIAZEM HYDROCHLORIDE | 120MG; 180MG; 240MG; 300MG; 360MG; 420MG | capsule, extended release · oral | CHARTWELL RX | Prescription | 28 Sep 2012 |
| DILTIAZEM HYDROCHLORIDE | 360MG | capsule, extended release · oral | ACTAVIS ELIZABETH | Prescription | 7 Dec 2012 |
| DILTIAZEM HYDROCHLORIDE | 360MG | capsule, extended release · oral | SUN PHARM | Prescription | 8 Jun 2017 |
| DILTIAZEM HYDROCHLORIDE | 120MG; 180MG; 240MG; 300MG; 360MG | capsule, extended release · oral | ZYDUS PHARMS | Prescription | 8 Aug 2017 |
| DILTIAZEM HYDROCHLORIDE | 120MG; 180MG; 240MG; 300MG; 360MG; 420MG | capsule, extended release · oral | ZYDUS PHARMS | Prescription | 11 Aug 2017 |
| DILTIAZEM HYDROCHLORIDE | 120MG; 180MG; 240MG; 300MG; 360MG | capsule, extended release · oral | TWI PHARMS | Prescription | 30 Aug 2018 |
| DILTIAZEM HYDROCHLORIDE | 120MG; 180MG; 240MG; 300MG; 360MG | capsule, extended release · oral | NOVAST LABS | Prescription | 14 Jun 2019 |
| DILTIAZEM HYDROCHLORIDE | 120MG; 180MG; 240MG | capsule, extended release · oral | ACCORD HLTHCARE | Prescription | 28 Apr 2020 |
| DILTIAZEM HYDROCHLORIDE | 60MG; 90MG; 120MG | capsule, extended release · oral | GLENMARK PHARMS LTD | Prescription | 22 Mar 2021 |
48 more — full table
Canada Canada — marketed products (Health Canada)
| Brand | DIN | Strength | Form · route | Company |
|---|---|---|---|---|
| AA-DILTIAZ | 00771376 | 30 MG | TABLET · ORAL | AA PHARMA INC |
| AA-DILTIAZ | 00771384 | 60 MG | TABLET · ORAL | AA PHARMA INC |
| APO-DILTIAZ CD | 02229526 | 300 MG | CAPSULE (CONTROLLED-DELIVERY) · ORAL | APOTEX INC |
| APO-DILTIAZ CD | 02230997 | 120 MG | CAPSULE (CONTROLLED-DELIVERY) · ORAL | APOTEX INC |
| APO-DILTIAZ CD | 02230998 | 180 MG | CAPSULE (CONTROLLED-DELIVERY) · ORAL | APOTEX INC |
| APO-DILTIAZ CD | 02230999 | 240 MG | CAPSULE (CONTROLLED-DELIVERY) · ORAL | APOTEX INC |
| DILTIAZEM CD | 02400421 | 120 MG | CAPSULE (CONTROLLED-DELIVERY) · ORAL | SANIS HEALTH INC |
| DILTIAZEM CD | 02400448 | 180 MG | CAPSULE (CONTROLLED-DELIVERY) · ORAL | SANIS HEALTH INC |
| DILTIAZEM CD | 02400456 | 240 MG | CAPSULE (CONTROLLED-DELIVERY) · ORAL | SANIS HEALTH INC |
| DILTIAZEM CD | 02400464 | 300 MG | CAPSULE (CONTROLLED-DELIVERY) · ORAL | SANIS HEALTH INC |
| DILTIAZEM CD | 02445999 | 120 MG | CAPSULE (EXTENDED-RELEASE) · ORAL | SIVEM PHARMACEUTICALS ULC |
| DILTIAZEM CD | 02446006 | 180 MG | CAPSULE (EXTENDED-RELEASE) · ORAL | SIVEM PHARMACEUTICALS ULC |
| DILTIAZEM CD | 02446014 | 240 MG | CAPSULE (EXTENDED-RELEASE) · ORAL | SIVEM PHARMACEUTICALS ULC |
| DILTIAZEM CD | 02446022 | 300 MG | CAPSULE (EXTENDED-RELEASE) · ORAL | SIVEM PHARMACEUTICALS ULC |
| DILTIAZEM HYDROCHLORIDE INJECTION | 02244728 | 5 MG / ML | SOLUTION · INTRAVENOUS | SANDOZ CANADA INCORPORATED |
| DILTIAZEM HYDROCHLORIDE INJECTION | 02514095 | 5 MG / ML | SOLUTION · INTRAVENOUS | OMEGA LABORATORIES LIMITED |
| DILTIAZEM T | 02516101 | 120 MG | CAPSULE (EXTENDED-RELEASE) · ORAL | SANIS HEALTH INC |
| DILTIAZEM T | 02516128 | 180 MG | CAPSULE (EXTENDED-RELEASE) · ORAL | SANIS HEALTH INC |
| DILTIAZEM T | 02516136 | 240 MG | CAPSULE (EXTENDED-RELEASE) · ORAL | SANIS HEALTH INC |
| DILTIAZEM T | 02516144 | 300 MG | CAPSULE (EXTENDED-RELEASE) · ORAL | SANIS HEALTH INC |
| DILTIAZEM T | 02516152 | 360 MG | CAPSULE (EXTENDED-RELEASE) · ORAL | SANIS HEALTH INC |
| JAMP DILTIAZEM CD | 02528037 | 120 MG | CAPSULE (CONTROLLED-DELIVERY) · ORAL | JAMP PHARMA CORPORATION |
| JAMP DILTIAZEM CD | 02528045 | 180 MG | CAPSULE (CONTROLLED-DELIVERY) · ORAL | JAMP PHARMA CORPORATION |
| JAMP DILTIAZEM CD | 02528053 | 240 MG | CAPSULE (CONTROLLED-DELIVERY) · ORAL | JAMP PHARMA CORPORATION |
| JAMP DILTIAZEM CD | 02528061 | 300 MG | CAPSULE (CONTROLLED-DELIVERY) · ORAL | JAMP PHARMA CORPORATION |
50 more — full table
Prices — United States and England
| Source | Product as listed | Price | Unit / pack | Date |
|---|---|---|---|---|
| US NADAC | CARTIA XT 120 MG CAPSULE | $0.14353 | per EA | 23 Sep 2026 |
| US NADAC | CARTIA XT 180 MG CAPSULE | $0.1873 | per EA | 23 Sep 2026 |
| US NADAC | CARTIA XT 240 MG CAPSULE | $0.19688 | per EA | 23 Sep 2026 |
| US NADAC | CARTIA XT 300 MG CAPSULE | $0.30196 | per EA | 23 Sep 2026 |
| US NADAC | DILTIAZEM 120 MG TABLET | $0.09903 | per EA | 23 Sep 2026 |
| US NADAC | DILTIAZEM 12HR ER 120 MG CAP | $1.97043 | per EA | 23 Sep 2026 |
| US NADAC | DILTIAZEM 12HR ER 60 MG CAP | $1.42657 | per EA | 23 Sep 2026 |
| US NADAC | DILTIAZEM 12HR ER 90 MG CAP | $1.66135 | per EA | 23 Sep 2026 |
| US NADAC | DILTIAZEM 24H ER(CD) 120 MG CP | $0.14353 | per EA | 23 Sep 2026 |
| US NADAC | DILTIAZEM 24H ER(CD) 180 MG CP | $0.1873 | per EA | 23 Sep 2026 |
| US NADAC | DILTIAZEM 24H ER(CD) 240 MG CP | $0.19688 | per EA | 23 Sep 2026 |
| US NADAC | DILTIAZEM 24H ER(CD) 300 MG CP | $0.30196 | per EA | 23 Sep 2026 |
| NHS Drug Tariff | Diltiazem 120mg modified-release capsules | £9.14 | 28 capsule | 1 Oct 2026 |
| NHS Drug Tariff | Diltiazem 120mg modified-release capsules | £9.45 | 56 capsule | 1 Oct 2026 |
| NHS Drug Tariff | Diltiazem 120mg modified-release tablets | £7.15 | 56 tablet | 1 Oct 2026 |
| NHS Drug Tariff | Diltiazem 180mg modified-release capsules | £10.37 | 28 capsule | 1 Oct 2026 |
| NHS Drug Tariff | Diltiazem 180mg modified-release capsules | £14.15 | 56 capsule | 1 Oct 2026 |
| NHS Drug Tariff | Diltiazem 200mg modified-release capsules | £6.29 | 28 capsule | 1 Oct 2026 |
| NHS Drug Tariff | Diltiazem 240mg modified-release capsules | £11.52 | 28 capsule | 1 Oct 2026 |
| NHS Drug Tariff | Diltiazem 300mg modified-release capsules | £9.01 | 28 capsule | 1 Oct 2026 |
| NHS Drug Tariff | Diltiazem 360mg modified-release capsules | £13.85 | 28 capsule | 1 Oct 2026 |
| NHS Drug Tariff | Diltiazem 60mg modified-release tablets | £4.24 | 84 tablet | 1 Oct 2026 |
| NHS Drug Tariff | Diltiazem 90mg modified-release capsules | £8.50 | 56 capsule | 1 Oct 2026 |
| NHS Drug Tariff | Diltiazem 90mg modified-release tablets | £7.27 | 56 tablet | 1 Oct 2026 |
NADAC: average price US retail pharmacies pay to buy the medicine. NHS Drug Tariff Part VIIIA: basic price reimbursed to pharmacies in England and Wales.
Safety signals and safety-related labeling changes
- US FDA 16 Apr 2025 TIAZAC — safety-related labeling change
Labeling sections changed: Adverse Reactions; Drug Interactions - US FDA 16 Apr 2025 CARDIZEM — safety-related labeling change
Labeling sections changed: Drug Interactions - US FDA 16 Apr 2025 CARDIZEM CD — safety-related labeling change
Labeling sections changed: Drug Interactions - US FDA 16 Apr 2025 CARDIZEM LA — safety-related labeling change
Labeling sections changed: Drug Interactions; Use in Specific Populations
Values as published by each source: SFDA human drug list (4-2026, as published by the Council of Health Insurance; indications from the CHI Daman Drug Formulary), Drugs@FDA, EMA medicines data, Health Canada Drug Product Database (Open Government Licence – Canada), CMS NADAC, NHS Drug Tariff Part VIIIA (NHSBSA Copyright, Open Government Licence v3.0), WHO Model List of Essential Medicines (CC BY 3.0 IGO; regrouped by active substance, not created by WHO), EMA PRAC, US FDA safety-related labeling changes and MHRA Drug Safety Update (Open Government Licence v3.0). Sources and reuse. Not a substitute for the official registers or the product information.