Active substances
Epinephrine + Lidocaine
- SFDA 7
- US FDA 36
- Health Canada 14
- NHS prices 3
- WHO EML 1
SFDA Saudi Arabia — SFDA human drug list
| Trade name | Strength | Form · route | Pack | Public price | Type | Company | Status |
|---|---|---|---|---|---|---|---|
| OCTACAINE 100 CARTRIDGE | 20,0.01 mg/ml,mg/ml | Solution · Dental use | 50 Cartridge | SAR 118.60 | Generic · Prescription | NOVOCOL | Valid |
| XYLOCAINE DENTAL ADRENALINE SOLU FOR INJ | 20,12.5 mg/ml,µ/ml | Solution for injection · Intravenous use | 100 Cartridge | SAR 183.10 | Generic · Prescription | PIERREL PHARMA S.P.A | Valid |
| LIDOCATON 2% 1:100,000 CARTRIDGES | 20, 0.01 mg/ml | Solution for injection · Intravenous use | 50 Cartridge | SAR 59.55 | Generic · Prescription | WEIMER PHARMA | Withdrawn by MAH · Not Marketed |
| LIDOCATON 2% 1:80,000 CARTRIDGES | 20, 0.0125 mg/ml | Solution for injection · Intravenous use | 50 Cartridge | SAR 59.55 | Generic · Prescription | WEIMER PHARMA | Withdrawn by MAH · Not Marketed |
| XYLOCAINE 0.5% W-ADREN. 5MCG-ML INJ | 0.5, 0.005 % | Solution for injection · Intravenous use | 5 Vial | SAR 42.00 | Generic · Prescription | AstraZeneca | Withdrawn by MAH · Not Marketed |
| XYLOCAINE 1% WITH ADRENALINE INJ | 1, 0.0005 % | Solution · Intravenous use | 5 Ampoule | SAR 68.95 | NCE · Prescription | AstraZeneca | Withdrawn by MAH · Not Marketed |
| XYLOCAINE 2% WITH ADRENALINE INJ SOLN | 2, 0.0005 % | Solution for injection · Intravenous use | 5 Ampoule | SAR 71.70 | NCE · Prescription | AstraZeneca | Withdrawn by MAH · Not Marketed |
Indications — CHI Daman Drug Formulary
ANESTHESIA; PAIN MANAGEMENT IN CANCER PATIENTS; POSTOPERATIVE PAIN; RENAL AND URETERIC STONES
US FDA United States — FDA approvals (Drugs@FDA)
| Product | Strength | Form · route | Applicant | Status | First approved |
|---|---|---|---|---|---|
| XYLOCAINE W/ EPINEPHRINE | 0.01MG/ML;1%; 0.02MG/ML;2%; 0.005MG/ML;0.5%; 0.005MG/ML;1.5%; 0.005MG/ML;1%; 0.005MG/ML;2% | injectable · injection | FRESENIUS KABI USA | Prescription | 19 Nov 1948 |
| LIGNOSPAN STANDARD | EQ 0.01MG BASE/ML;2% | injectable · injection | DEPROCO | Prescription | 22 Jan 1985 |
| LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE | 0.005MG/ML;1.5% | injectable · injection | HOSPIRA | Prescription | 13 Sep 1985 |
| LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE | 0.005MG/ML;0.5% | injectable · injection | HOSPIRA | Prescription | 21 Jun 1988 |
| LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE | 0.01MG/ML;1% | injectable · injection | HOSPIRA | Prescription | 21 Jun 1988 |
| LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE | 0.005MG/ML;1.5% | injectable · injection | HOSPIRA | Prescription | 21 Jun 1988 |
| LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE | 0.01MG/ML;2% | injectable · injection | HOSPIRA | Prescription | 21 Jun 1988 |
| LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE | 0.005MG/ML;2% | injectable · injection | HOSPIRA | Prescription | 21 Jun 1988 |
| LIGNOSPAN FORTE | EQ 0.02MG BASE/ML;2% | injectable · injection | DEPROCO | Prescription | 30 Sep 2009 |
| LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE | 0.005MG/ML;1.5% | injectable · injection | B BRAUN MEDICAL | Prescription | 8 Sep 2021 |
| FLAVALTA | EQ 0.017MG BASE/1.7ML (EQ 0.01MG BASE/ML);34MG/1.7ML (20MG/ML) | solution · injection | DEPROCO | Prescription | 19 Mar 2026 |
| XYLOCAINE W/ EPINEPHRINE | 0.01MG/ML;2% | injectable · injection | FRESENIUS KABI USA | Discontinued | 19 Nov 1948 |
| XYLOCAINE DENTAL WITH EPINEPHRINE | 0.01MG/ML;2% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**; 0.02MG/ML;2% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | injectable · injection | DENTSPLY PHARM | Discontinued | 19 Nov 1948 |
| LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE | 0.01MG/ML;2%; 0.02MG/ML;2% | injectable · injection | BELMORA LLC | Discontinued | 23 Feb 1972 |
| LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE | 0.01MG/ML;1%; 0.01MG/ML;2% | injectable · injection | WEST-WARD PHARMS INT | Discontinued | 13 Mar 1972 |
| LIDOCAINE HYDROCHLORIDE W/ EPINEPHRINE | 0.01MG/ML;1% | injectable · injection | ABBOTT | Discontinued | 20 Dec 1972 |
| LIDOCAINE HYDROCHLORIDE W/ EPINEPHRINE | 0.01MG/ML;2% | injectable · injection | BEL MAR | Discontinued | 3 Dec 1973 |
| LIDOCAINE HYDROCHLORIDE W/ EPINEPHRINE | 0.01MG/ML;1% | injectable · injection | BEL MAR | Discontinued | 3 Dec 1973 |
| LIDOCAINE HYDROCHLORIDE W/ EPINEPHRINE | 0.01MG/ML;1%; 0.01MG/ML;2% | injectable · injection | WATSON LABS | Discontinued | 20 Feb 1974 |
| LIDOCAINE HYDROCHLORIDE W/ EPINEPHRINE | 0.01MG/ML;1% | injectable · injection | DELL LABS | Discontinued | 18 Mar 1975 |
| LIDOCAINE HYDROCHLORIDE W/ EPINEPHRINE | 0.01MG/ML;2% | injectable · injection | DELL LABS | Discontinued | 18 Mar 1975 |
| ALPHACAINE HYDROCHLORIDE W/ EPINEPHRINE | 0.01MG/ML;2% | injectable · injection | CARLISLE | Discontinued | 16 Jan 1976 |
| ALPHACAINE HYDROCHLORIDE W/ EPINEPHRINE | 0.02MG/ML;2% | injectable · injection | CARLISLE | Discontinued | 21 Jan 1976 |
| LIDOCAINE HYDROCHLORIDE W/ EPINEPHRINE | 0.01MG/ML;1% | injectable · injection | INTL MEDICATION | Discontinued | 4 Feb 1980 |
| OCTOCAINE | 0.01MG/ML;2%; 0.02MG/ML;2% | injectable · injection | SEPTODONT | Discontinued | 9 Sep 1980 |
11 more — full table
Canada Canada — marketed products (Health Canada)
| Brand | DIN | Strength | Form · route | Company |
|---|---|---|---|---|
| LIDOCAINE 2% AND EPINEPHRINE 1:100,000 | 02473518 | 20 MG / ML; 0.01 MG / ML | SOLUTION · BLOCK/INFILTRATION | SEPTODONT |
| LIDOCAINE 2% AND EPINEPHRINE 1:50,000 | 02473526 | 20 MG / ML; 0.02 MG / ML | SOLUTION · BLOCK/INFILTRATION | SEPTODONT |
| LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE INJECTION USP | 01901915 | 20 MG / ML; 0.01 MG / ML | SOLUTION · BLOCK/INFILTRATION | PFIZER CANADA ULC |
| LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE INJECTION USP | 02436221 | 20 MG / ML; 0.01 MG / ML | SOLUTION · BLOCK/INFILTRATION | HIKMA CANADA LIMITED |
| LIGNOSPAN FORTE | 00375799 | 36 MCG / 1.8 ML; 36 MG / 1.8 ML | SOLUTION · BLOCK/INFILTRATION | SEPTODONT |
| LIGNOSPAN STANDARD | 00375780 | 36 MG / 1.8 ML; 18 MCG / 1.8 ML | SOLUTION · BLOCK/INFILTRATION | SEPTODONT |
| OCTOCAINE HCL 2% EPINEPHRINE 1:100000 | 00151866 | 20 MG / ML; 0.01 MG / ML | SOLUTION · SUBCUTANEOUS | NOVOCOL PHARMACEUTICAL OF CANADA INC |
| THE SOLUTION ANORECTAL SPRAY TEMPORARY PAIN RELIEF | 02530422 | 0.01 %; 5 % | SPRAY · TOPICAL | SCALP TECH INC. |
| XYLOCAINE 1% W EPINEPHRINE 1:100000 | 00001791 | 10 MG / ML; 0.01 MG / ML | SOLUTION · BLOCK/INFILTRATION | ASPEN PHARMACARE CANADA INC. |
| XYLOCAINE 1% W EPINEPHRINE 1:200000 | 00001805 | 5 MCG / ML; 10 MG / ML | SOLUTION · BLOCK/INFILTRATION | ASPEN PHARMACARE CANADA INC. |
| XYLOCAINE 2% W EPINEPHRINE 1:200000 | 00284106 | 20 MG / ML; 5 MCG / ML | SOLUTION · EPIDURAL | ASPEN PHARMACARE CANADA INC. |
| XYLOCAINE 2% WITH EPINEPHRINE 1:200000 | 02373130 | 20 MG / ML; 0.005 MG / ML | SOLUTION · BLOCK/INFILTRATION | ASPEN PHARMACARE CANADA INC. |
| XYLOCAINE DENTAL LIDOCAINE HCL 2% AND EPINEPHRINE 1:100,000 | 02331640 | 20 MG / ML; 0.01 MG / ML | SOLUTION · BLOCK/INFILTRATION | DENTSPLY CANADA LIMITED |
| XYLOCAINE DENTAL LIDOCAINE HYDROCHLORIDE 2% AND EPINEPHRINE 1:50,000 | 02345072 | 0.02 MG / ML; 20 MG / ML | SOLUTION · BLOCK/INFILTRATION | DENTSPLY CANADA LIMITED |
Prices — United States and England
| Source | Product as listed | Price | Unit / pack | Date |
|---|---|---|---|---|
| NHS Drug Tariff | Lidocaine 36mg/1.8ml (2%) / Adrenaline (base) 22.5micrograms/1.8ml (1 in 80,000) solution for injection cartridges | £35.90 | 50 cartridge | 1 Oct 2026 |
| NHS Drug Tariff | Lidocaine 400mg/20ml (2%) / Adrenaline (base) 100micrograms/20ml (1 in 200,000) solution for injection vials | £10.55 | 5 vial | 1 Oct 2026 |
| NHS Drug Tariff | Lidocaine 44mg/2.2ml (2%) / Adrenaline (base) 27.5micrograms/2.2ml (1 in 80,000) solution for injection cartridges | £35.90 | 50 cartridge | 1 Oct 2026 |
NADAC: average price US retail pharmacies pay to buy the medicine. NHS Drug Tariff Part VIIIA: basic price reimbursed to pharmacies in England and Wales.
WHO WHO Model List of Essential Medicines (2025)
- 1.2. Local anaesthetics · core
Local anaesthetics
Parenteral > Locoregional injections > Other: 1% (lidocaine hydrochloride OR lidocaine sulfate) + 1:200 000 epinephrine; 2% (lidocaine hydrochloride OR lidocaine sulfate) + 1:200 000 epinephrine | Local > Dental > Cartridge: 2% (lidocaine hydrochloride) + 1:80 000 epinephrine
Components
Values as published by each source: SFDA human drug list (4-2026, as published by the Council of Health Insurance; indications from the CHI Daman Drug Formulary), Drugs@FDA, EMA medicines data, Health Canada Drug Product Database (Open Government Licence – Canada), CMS NADAC, NHS Drug Tariff Part VIIIA (NHSBSA Copyright, Open Government Licence v3.0), WHO Model List of Essential Medicines (CC BY 3.0 IGO; regrouped by active substance, not created by WHO), EMA PRAC, US FDA safety-related labeling changes and MHRA Drug Safety Update (Open Government Licence v3.0). Sources and reuse. Not a substitute for the official registers or the product information.