Cyanokit SERB SA · Authorised · authorised 23 Nov 2007 · ATC V03AB33
Therapeutic indication (EMA)
Treatment of known or suspected cyanide poisoning. Cyanokit is to be administered together with appropriate decontamination and supportive measures.
Active substance
Hydroxocobalamin
- SFDA 2
- US FDA 7
- EMA 1
- Health Canada 1
- US price lines 1
- NHS prices 1
- WHO EML 1
- Safety 1
SFDA Saudi Arabia — SFDA human drug list
| Trade name | Strength | Form · route | Pack | Public price | Type | Company | Status |
|---|---|---|---|---|---|---|---|
| DEPOVIT B12 1000 AMP 1ML | 1.04 mg | Solution for injection · Intramuscular use | 2 Ampoule | SAR 7.85 | Generic · Prescription | ALAMRIAH FOR PHARMACEUTICALS INDUSTRIES | Valid |
| Depovit B12 | 1 mg | Solution for injection · Intramuscular use | 5 Ampoule | SAR 19.60 | Generic · Prescription | AMRIYA FOR PHARMACEUTICAL INDUSTRIES | Valid |
Indications — CHI Daman Drug Formulary
BARIATRIC SURGERY; NON-SMALL-CELL LUNG CARCINOMA (NSCLC); VITAMIN B12 DEFICENCY ANEMIA
US FDA United States — FDA approvals (Drugs@FDA)
| Product | Strength | Form · route | Applicant | Status | First approved |
|---|---|---|---|---|---|
| HYDROXOCOBALAMIN | 1MG/ML | injectable · injection | ACTAVIS | Prescription | 16 Aug 1978 |
| CYANOKIT | 5GM/VIAL (5GM/KIT) | injectable · injection | BTG INTL | Prescription | 15 Dec 2006 |
| ALPHAREDISOL | 1MG/ML | injectable · injection | MERCK | Discontinued | 18 Apr 1975 |
| HYDROXOMIN | 1MG/ML | injectable · injection | BEL MAR | Discontinued | 1 May 1981 |
| CYANOKIT | 2.5GM/VIAL (5GM/KIT) | injectable · injection | BTG INTL | Discontinued | 15 Dec 2006 |
| HYDROXOCOBALAMIN | 1MG/ML | injectable · injection | ABRAXIS PHARM | Discontinued | |
| HYDROXOCOBALAMIN | 1MG/ML | injectable · injection | WATSON LABS | Discontinued |
EMA European Union — centrally authorised medicines
Canada Canada — marketed products (Health Canada)
| Brand | DIN | Strength | Form · route | Company |
|---|---|---|---|---|
| CYANOKIT | 02375370 | 5 G / VIAL | POWDER FOR SOLUTION · INTRAVENOUS | SERB S.A. |
Prices — United States and England
| Source | Product as listed | Price | Unit / pack | Date |
|---|---|---|---|---|
| US NADAC | HYDROXOCOBALAMIN 1,000 MCG/ML | $0.8144 | per ML | 18 Mar 2026 |
| NHS Drug Tariff | Hydroxocobalamin 1mg/1ml solution for injection ampoules | £9.71 | 5 ampoule | 1 Oct 2026 |
NADAC: average price US retail pharmacies pay to buy the medicine. NHS Drug Tariff Part VIIIA: basic price reimbursed to pharmacies in England and Wales.
WHO WHO Model List of Essential Medicines (2025)
- 10.1. Antianaemia medicines · core
Megaloblastic anaemia due to vitamin B12 deficiency
Parenteral > General injections > IM: 1 mg per mL in 1 mL ampoule (as acetate); 1 mg per mL in 1 mL ampoule (as hydrochloride); 1 mg per mL in 1 mL ampoule (as sulfate)
Safety signals and safety-related labeling changes
- US FDA 31 Dec 2018 CYANOKIT — safety-related labeling change
Labeling sections changed: Warnings and Precautions; Adverse Reactions; Drug Interactions; Use in Specific Populations; Patient Counseling Information / Patient Information / Medication Guide
Combinations containing Hydroxocobalamin
Values as published by each source: SFDA human drug list (4-2026, as published by the Council of Health Insurance; indications from the CHI Daman Drug Formulary), Drugs@FDA, EMA medicines data, Health Canada Drug Product Database (Open Government Licence – Canada), CMS NADAC, NHS Drug Tariff Part VIIIA (NHSBSA Copyright, Open Government Licence v3.0), WHO Model List of Essential Medicines (CC BY 3.0 IGO; regrouped by active substance, not created by WHO), EMA PRAC, US FDA safety-related labeling changes and MHRA Drug Safety Update (Open Government Licence v3.0). Sources and reuse. Not a substitute for the official registers or the product information.