Active substance
Letrozole
- SFDA 13
- US FDA 22
- Health Canada 18
- US price lines 2
- NHS prices 1
- WHO EML 1
- Safety 2
SFDA Saudi Arabia — SFDA human drug list
| Trade name | Strength | Form · route | Pack | Public price | Type | Company | Status |
|---|---|---|---|---|---|---|---|
| FEMAPLEX 2.5 mg film-coated tablet | 2.5 mg | Film-coated tablet · Oral use | 30 Blister | SAR 136.55 | Generic · Prescription | GENEPHARM S.A. | Valid |
| FEMARA 2.5 MG TABLET | 2.5 mg | Film-coated tablet · Oral use | 30 Blister | SAR 183.55 | NCE · Prescription | NOVARTIS PHARMA AG | Valid |
| LETARA 2.5 mg tablet | 2.5 mg | Film-coated tablet · Oral use | 30 Single Dose Container | SAR 156.55 | Generic · Prescription | DOUGLAS MANUFACTURING Ltd | Valid |
| ROZLET 2.5 MG FILM COATED TABLET | 2.5 mg | Film-coated tablet · Oral use | 10 Blister | SAR 56.20 | Generic · Prescription | SPIMACO ADDWAEIH | Valid |
| ROZLET 2.5 mg film-coated tablet | 2.5 mg | Film-coated tablet · Oral use | 30 Blister | SAR 165.20 | Generic · Prescription | SPIMACO ADDWAEIH | Valid |
| TREZOL 2.5 mg film-coated tablet | 2.5 mg | Film-coated tablet · Oral use | 30 Blister | SAR 165.20 | Generic · Prescription | LABORATORIOS CINFA SA | Valid |
| XOROLA 2.5MG F.C.TABLET | 2.5 mg | Film-coated tablet · Oral use | 30 Blister | SAR 115.65 | Generic · Prescription | Boston Oncology Arabia | Valid |
| LETRASAN 2.5MG F.C.TABLET | 2.5 mg | Film-coated tablet · Oral use | 30 Blister | SAR 68.45 | Generic · Prescription | DEVA HOLDING A.S. | Suspended |
| FEMARA 2.5 MG TABLET | 2.5 mg | Film-coated tablet · Oral use | 30 Blister | SAR 506.85 | NCE · Prescription | NOVARTIS | Withdrawn by MAH · Not Marketed |
| LEFFTARA 2.5 mg film-coated tablet | 2.5 mg | Film-coated tablet · Oral use | 30 Blister | SAR 168.60 | Generic · Prescription | Hikma Pharmaceuticals PLC | Withdrawn by MAH · Not Marketed |
| LEZODEX 2.5 mg tablet | 2.5 mg | Film-coated tablet · Oral use | 30 Blister | SAR 165.20 | Generic · Prescription | APOTEX | Withdrawn by MAH · Not Marketed |
| LOXOPREL 2.5 mg film-coated tablet | 2.5 mg | Film-coated tablet · Oral use | 30 Blister | SAR 261.70 | Generic · Prescription | ACTAVIS | Withdrawn by MAH · Not Marketed |
| MARLET 2.5 MG F.C. TABLET | 2.5 mg | Film-coated tablet · Oral use | 30 Blister | SAR 165.20 | Generic · Prescription | SAJA-SAUDI ARABIAN JAPANESE PHARMACEUTICAL CO | Withdrawn by MAH · Not Marketed |
Indications — CHI Daman Drug Formulary
BREAST CANCER EARLY HORMONAL; BREAST CANCER MET.HORMONAL; ENDOMETRIOSIS; OVARIAN CANCER
US FDA United States — FDA approvals (Drugs@FDA)
| Product | Strength | Form · route | Applicant | Status | First approved |
|---|---|---|---|---|---|
| FEMARA | 2.5MG | tablet · oral | NOVARTIS PHARMS | Prescription | 25 Jul 1997 |
| LETROZOLE | 2.5MG | tablet · oral | TEVA PHARMS | Prescription | 3 Jun 2011 |
| LETROZOLE | 2.5MG | tablet · oral | ACCORD HLTHCARE | Prescription | 3 Jun 2011 |
| LETROZOLE | 2.5MG | tablet · oral | PHARMOBEDIENT | Prescription | 3 Jun 2011 |
| LETROZOLE | 2.5MG | tablet · oral | NATCO PHARMA LTD | Prescription | 3 Jun 2011 |
| LETROZOLE | 2.5MG | tablet · oral | BEIJING YILING | Prescription | 14 Nov 2018 |
| LETROZOLE | 2.5MG | tablet · oral | EUGIA PHARMA | Prescription | 11 Jan 2019 |
| LETROZOLE | 2.5MG | tablet · oral | ZYDUS LIFESCIENCES | Prescription | 14 Sep 2026 |
| LETROZOLE | 2.5MG | tablet · oral | PHARMOBEDIENT | Discontinued | 24 Dec 2008 |
| LETROZOLE | 2.5MG | tablet · oral | FRESENIUS KABI USA | Discontinued | 3 Jun 2011 |
| LETROZOLE | 2.5MG | tablet · oral | STRIDES PHARMA INTL | Discontinued | 3 Jun 2011 |
| LETROZOLE | 2.5MG | tablet · oral | HIKMA PHARMS | Discontinued | 3 Jun 2011 |
| LETROZOLE | 2.5MG | tablet · oral | LANNETT CO INC | Discontinued | 3 Jun 2011 |
| LETROZOLE | 2.5MG | tablet · oral | SUN PHARM INDS LTD | Discontinued | 3 Jun 2011 |
| LETROZOLE | 2.5MG | tablet · oral | IMPAX LABS | Discontinued | 3 Jun 2011 |
| LETROZOLE | 2.5MG | tablet · oral | INDICUS PHARMA | Discontinued | 3 Jun 2011 |
| LETROZOLE | 2.5MG | tablet · oral | ACTAVIS TOTOWA | Discontinued | 13 Jul 2011 |
| LETROZOLE | 2.5MG | tablet · oral | APOTEX INC | Discontinued | 19 Apr 2012 |
| LETROZOLE | 2.5MG | tablet · oral | CHARTWELL RX | Discontinued | 16 May 2013 |
| LETROZOLE | 2.5MG | tablet · oral | LANNETT CO INC | Discontinued | 29 Oct 2014 |
| LETROZOLE | 2.5MG | tablet · oral | HIKMA PHARMS | Discontinued | 3 Jun 2016 |
| LETROZOLE | 2.5MG | tablet · oral | SYNTHON PHARMS | Discontinued |
Canada Canada — marketed products (Health Canada)
| Brand | DIN | Strength | Form · route | Company |
|---|---|---|---|---|
| ACH-LETROZOLE | 02338459 | 2.5 MG | TABLET · ORAL | ACCORD HEALTHCARE INC |
| AG-LETROZOLE TABLETS | 02543419 | 2.5 MG | TABLET · ORAL | ANGITA PHARMA INC. |
| APO-LETROZOLE | 02358514 | 2.5 MG | TABLET · ORAL | APOTEX INC |
| BIO-LETROZOLE | 02392496 | 2.5 MG | TABLET · ORAL | BIOMED PHARMA |
| FEMARA | 02231384 | 2.5 MG | TABLET · ORAL | NOVARTIS PHARMACEUTICALS CANADA INC |
| JAMP LETROZOLE TABLETS | 02541912 | 2.5 MG | TABLET · ORAL | JAMP PHARMA CORPORATION |
| LETROZOLE | 02402025 | 2.5 MG | TABLET · ORAL | PRO DOC LIMITEE |
| LETROZOLE | 02504472 | 2.5 MG | TABLET · ORAL | SANIS HEALTH INC |
| LETROZOLE | 02524244 | 2.5 MG | TABLET · ORAL | SIVEM PHARMACEUTICALS ULC |
| M-LETROZOLE | 02549972 | 2.5 MG | TABLET · ORAL | MANTRA PHARMA INC |
| MAR-LETROZOLE | 02373424 | 2.5 MG | TABLET · ORAL | MARCAN PHARMACEUTICALS INC |
| MINT-LETROZOLE | 02508109 | 2.5 MG | TABLET · ORAL | MINT PHARMACEUTICALS INC |
| NAT-LETROZOLE | 02421585 | 2.5 MG | TABLET · ORAL | NATCO PHARMA (CANADA) INC |
| NRA-LETROZOLE | 02520486 | 2.5 MG | TABLET · ORAL | NORA PHARMA INC |
| PMS-LETROZOLE | 02309114 | 2.5 MG | TABLET · ORAL | PHARMASCIENCE INC |
| RIVA-LETROZOLE | 02398656 | 2.5 MG | TABLET · ORAL | LABORATOIRE RIVA INC. |
| SANDOZ LETROZOLE | 02344815 | 2.5 MG | TABLET · ORAL | SANDOZ CANADA INCORPORATED |
| TEVA-LETROZOLE | 02343657 | 2.5 MG | TABLET · ORAL | TEVA CANADA LIMITED |
Prices — United States and England
| Source | Product as listed | Price | Unit / pack | Date |
|---|---|---|---|---|
| US NADAC | FEMARA 2.5 MG TABLET | $27.11602 | per EA | 7 Jan 2026 |
| US NADAC | LETROZOLE 2.5 MG TABLET | $0.14498 | per EA | 23 Sep 2026 |
| NHS Drug Tariff | Letrozole 2.5mg tablets | £2.14 | 28 tablet | 1 Oct 2026 |
NADAC: average price US retail pharmacies pay to buy the medicine. NHS Drug Tariff Part VIIIA: basic price reimbursed to pharmacies in England and Wales.
WHO WHO Model List of Essential Medicines (2025)
- 22.2. Ovulation inducers · complementary
Female infertility without specification whether primary or secondary
Oral > Solid > dosage form: 2.5 mg
Safety signals and safety-related labeling changes
- US FDA 1 Jul 2026 KISQALI FEMARA CO-PACK (COPACKAGED) — safety-related labeling change
Labeling sections changed: Contraindications; Warnings and Precautions; Adverse Reactions; Drug Interactions; Use in Specific Populations; Patient Counseling Information / Patient Information / Medication Guide - US FDA 16 Dec 2024 FEMARA — safety-related labeling change
Labeling sections changed: Contraindications; Warnings and Precautions; Adverse Reactions; Drug Interactions; Use in Specific Populations; Patient Counseling Information / Patient Information / Medication Guide
Values as published by each source: SFDA human drug list (4-2026, as published by the Council of Health Insurance; indications from the CHI Daman Drug Formulary), Drugs@FDA, EMA medicines data, Health Canada Drug Product Database (Open Government Licence – Canada), CMS NADAC, NHS Drug Tariff Part VIIIA (NHSBSA Copyright, Open Government Licence v3.0), WHO Model List of Essential Medicines (CC BY 3.0 IGO; regrouped by active substance, not created by WHO), EMA PRAC, US FDA safety-related labeling changes and MHRA Drug Safety Update (Open Government Licence v3.0). Sources and reuse. Not a substitute for the official registers or the product information.