Is Methoxyflurane registered with the SFDA?

The SFDA human drug list (edition 4-2026, as published by the Council of Health Insurance) lists 3 valid registrations of Methoxyflurane, including PENTHROX 99.9 % liquid for inhalation (99.9 %, Inhalation vapour, liquid, SAR 1121.50).

Is Methoxyflurane approved by the US FDA?

Drugs@FDA lists 1 application product line for Methoxyflurane, including PENTHRANE (Discontinued).

Active substance

Methoxyflurane

SFDA 3
US FDA 1
Health Canada 2

Open in the medicines table

SFDA Saudi Arabia — SFDA human drug list

Trade name	Strength	Form · route	Pack	Public price	Type	Company	Status
PENTHROX 99.9 % liquid for inhalation	99.9 %	Inhalation vapour, liquid · Inhalation use	10 Bottle	SAR 1121.50	NCE · Prescription	Medical Developments International Limited	Valid
PENTHROX 99.9 % liquid for inhalation	99.9 %	Inhalation vapour, liquid · Inhalation use	1 Bottle	SAR 125.00	NCE · Prescription	Medical Developments International Limited	Valid
PENTHROX 99.9 % liquid for inhalation	99.9 %	Inhalation vapour, liquid · Inhalation use	10 Bottle	SAR 800.00	NCE · Prescription	Medical Developments International Limited	Valid

Indications — CHI Daman Drug Formulary

ANESTHESIA

US FDA United States — FDA approvals (Drugs@FDA)

Product	Strength	Form · route	Applicant	Status	First approved
PENTHRANE	99.9%	liquid · inhalation	ABBOTT	Discontinued	4 May 1962

Canada Canada — marketed products (Health Canada)

Brand	DIN	Strength	Form · route	Company
PENTHROX	02474719	99.9 %	SOLUTION · INHALATION	KNIGHT THERAPEUTICS INC.
PENTHROX	02474727	99.9 %	SOLUTION; KIT · INHALATION	KNIGHT THERAPEUTICS INC.

Values as published by each source: SFDA human drug list (4-2026, as published by the Council of Health Insurance; indications from the CHI Daman Drug Formulary), Drugs@FDA, EMA medicines data, Health Canada Drug Product Database (Open Government Licence – Canada), CMS NADAC, NHS Drug Tariff Part VIIIA (NHSBSA Copyright, Open Government Licence v3.0), WHO Model List of Essential Medicines (CC BY 3.0 IGO; regrouped by active substance, not created by WHO), EMA PRAC, US FDA safety-related labeling changes and MHRA Drug Safety Update (Open Government Licence v3.0). Sources and reuse. Not a substitute for the official registers or the product information.