Active substance
Metoprolol
- SFDA 11
- US FDA 69
- Health Canada 30
- US price lines 15
- NHS prices 3
- WHO EML 4
- Safety 5
SFDA Saudi Arabia — SFDA human drug list
| Trade name | Strength | Form · route | Pack | Public price | Type | Company | Status |
|---|---|---|---|---|---|---|---|
| CARELIO | 25 mg | Tablet · Oral use | 30 Blister | SAR 14.25 | Generic · Prescription | ACINO PHARMA AG | Valid |
| CARELIO | 50 mg | Tablet · Oral use | 30 Blister | SAR 23.40 | Generic · Prescription | ACINO PHARMA AG | Valid |
| CARELIO | 100 mg | Tablet · Oral use | 30 Blister | SAR 36.40 | Generic · Prescription | ACINO PHARMA AG | Valid |
| CARELIO | 200 mg | Tablet · Oral use | 30 Blister | SAR 42.25 | Generic · Prescription | ACINO PHARMA AG | Valid |
| Matroda | 50 mg | Film-coated tablet · Oral use | 40 Blister | SAR 17.05 | Generic · Prescription | DAR ALDAWA | Valid |
| Matroda | 100 mg | Film-coated tablet · Oral use | 40 Blister | SAR 29.40 | Generic · Prescription | DAR ALDAWA | Valid |
| Metolina | 100 mg | Film-coated tablet · Oral use | 30 Blister | SAR 23.20 | Generic · Prescription | Aurobindo Pharma Saudi Arabia Limited | Valid |
| Metolina | 50 mg | Film-coated tablet · Oral use | 30 Blister | SAR 13.45 | Generic · Prescription | Aurobindo Pharma Saudi Arabia Limited | Valid |
| LOPRESOR 100MG TAB | 100 mg | Tablet · Oral use | 20 Tablet Container | SAR 22.10 | NCE · Prescription | NOVARTIS | Withdrawn by MAH · Not Marketed |
| LOPRESOR 50MG TABS | 50 mg | Tablet · Oral use | 40 Tablet Container | SAR 22.10 | NCE · Prescription | NOVARTIS | Withdrawn by MAH · Not Marketed |
| LOPRESOR DIVI TAB 200 MG. | 200 mg | Tablet · Oral use | 14 Blister | SAR 34.80 | NCE · Prescription | NOVARTIS | Withdrawn by MAH · Not Marketed |
Indications — CHI Daman Drug Formulary
ARRHYTHMIA; CARDIOMYOPATHY; CONGESTIVE HEART FAILURE; CORONARY ARTERY DISEASE; PRE-ECLAMPSIA
US FDA United States — FDA approvals (Drugs@FDA)
| Product | Strength | Form · route | Applicant | Status | First approved |
|---|---|---|---|---|---|
| LOPRESSOR | 50MG; 100MG | tablet · oral | VALIDUS PHARMS | Prescription | 7 Aug 1978 |
| TOPROL-XL | EQ 50MG TARTRATE; EQ 100MG TARTRATE; EQ 200MG TARTRATE; EQ 25MG TARTRATE | tablet, extended release · oral | MELINTA THERAP | Prescription | 10 Jan 1992 |
| METOPROLOL TARTRATE | 50MG; 100MG | tablet · oral | ADAPTIS | Prescription | 27 Apr 1995 |
| METOPROLOL TARTRATE | 50MG; 100MG | tablet · oral | SUN PHARM INDS INC | Prescription | 10 Dec 1996 |
| METOPROLOL TARTRATE | 1MG/ML | injectable · injection | HIKMA PHARMS | Prescription | 7 Jul 2003 |
| METOPROLOL TARTRATE | 25MG; 50MG; 100MG; 37.5MG; 75MG | tablet · oral | MYLAN | Prescription | 16 Jan 2004 |
| METOPROLOL TARTRATE | 1MG/ML | injectable · injection | HIKMA FARMACEUTICA | Prescription | 30 May 2007 |
| METOPROLOL TARTRATE | 25MG; 50MG; 100MG; 37.5MG; 75MG | tablet · oral | AUROBINDO PHARMA | Prescription | 11 Sep 2007 |
| METOPROLOL TARTRATE | 1MG/ML | injectable · injection | SANDOZ | Prescription | 2 Oct 2007 |
| METOPROLOL TARTRATE | 1MG/ML | injectable · injection | HOSPIRA | Prescription | 29 Apr 2008 |
| METOPROLOL TARTRATE | 25MG; 50MG; 100MG | tablet · oral | IPCA LABS LTD | Prescription | 17 Jun 2008 |
| METOPROLOL SUCCINATE | EQ 50MG TARTRATE | tablet, extended release · oral | ACTAVIS LABS FL INC | Prescription | 3 Aug 2009 |
| METOPROLOL SUCCINATE | EQ 25MG TARTRATE; EQ 50MG TARTRATE; EQ 100MG TARTRATE; EQ 200MG TARTRATE | tablet, extended release · oral | WOCKHARDT BIO AG | Prescription | 22 Jul 2010 |
| METOPROLOL TARTRATE | 1MG/ML | injectable · injection | FRESENIUS KABI USA | Prescription | 25 Oct 2010 |
| METOPROLOL SUCCINATE | EQ 25MG TARTRATE; EQ 50MG TARTRATE | tablet, extended release · oral | DR REDDYS LABS LTD | Prescription | 1 Aug 2012 |
| METOPROLOL SUCCINATE | EQ 100MG TARTRATE; EQ 200MG TARTRATE | tablet, extended release · oral | REDDYS | Prescription | 15 Aug 2012 |
| METOPROLOL TARTRATE | 1MG/ML | injectable · injection | BAXTER HLTHCARE CORP | Prescription | 29 Apr 2013 |
| METOPROLOL TARTRATE | 25MG; 50MG; 100MG | tablet · oral | ALEMBIC PHARMS LTD | Prescription | 28 May 2013 |
| METOPROLOL TARTRATE | 1MG/ML | injectable · injection | GLAND | Prescription | 27 Aug 2014 |
| METOPROLOL TARTRATE | 25MG; 50MG; 100MG; 37.5MG; 75MG | tablet · oral | RUBICON RESEARCH | Prescription | 28 Oct 2014 |
| METOPROLOL SUCCINATE | EQ 25MG TARTRATE; EQ 50MG TARTRATE; EQ 100MG TARTRATE; EQ 200MG TARTRATE | tablet, extended release · oral | ACTAVIS ELIZABETH | Prescription | 25 Nov 2016 |
| KAPSPARGO SPRINKLE | EQ 25MG TARTRATE; EQ 50MG TARTRATE; EQ 100MG TARTRATE; EQ 200MG TARTRATE | capsule, extended release · oral | SPIL | Prescription | 26 Jan 2018 |
| METOPROLOL SUCCINATE | EQ 25MG TARTRATE; EQ 50MG TARTRATE; EQ 100MG TARTRATE; EQ 200MG TARTRATE | tablet, extended release · oral | NOVAST LABS | Prescription | 6 Feb 2018 |
| METOPROLOL SUCCINATE | EQ 25MG TARTRATE; EQ 50MG TARTRATE; EQ 100MG TARTRATE; EQ 200MG TARTRATE | tablet, extended release · oral | ZYDUS PHARMS | Prescription | 23 Mar 2018 |
| METOPROLOL SUCCINATE | EQ 50MG TARTRATE; EQ 100MG TARTRATE; EQ 200MG TARTRATE | tablet, extended release · oral | CIPLA | Prescription | 26 Oct 2018 |
44 more — full table
Canada Canada — marketed products (Health Canada)
| Brand | DIN | Strength | Form · route | Company |
|---|---|---|---|---|
| AA-METOPROLOL SR | 02285169 | 100 MG | TABLET (EXTENDED-RELEASE) · ORAL | AA PHARMA INC |
| APO-METOPROLOL | 00618632 | 50 MG | TABLET · ORAL | APOTEX INC |
| APO-METOPROLOL | 00618640 | 100 MG | TABLET · ORAL | APOTEX INC |
| APO-METOPROLOL | 02246010 | 25 MG | TABLET · ORAL | APOTEX INC |
| APO-METOPROLOL (TYPE L) | 00749354 | 50 MG | TABLET · ORAL | APOTEX INC |
| APO-METOPROLOL (TYPE L) | 00751170 | 100 MG | TABLET · ORAL | APOTEX INC |
| JAMP-METOPROLOL-L | 02356813 | 25 MG | TABLET · ORAL | JAMP PHARMA CORPORATION |
| JAMP-METOPROLOL-L | 02356821 | 50 MG | TABLET · ORAL | JAMP PHARMA CORPORATION |
| JAMP-METOPROLOL-L | 02356848 | 100 MG | TABLET · ORAL | JAMP PHARMA CORPORATION |
| METOPROLOL | 02350394 | 50 MG | TABLET · ORAL | SANIS HEALTH INC |
| METOPROLOL | 02350408 | 100 MG | TABLET · ORAL | SANIS HEALTH INC |
| METOPROLOL TARTRATE INJECTION USP | 02267853 | 1 MG / 1 ML | SOLUTION · INTRAVENOUS | SANDOZ CANADA INCORPORATED |
| METOPROLOL TARTRATE INJECTION USP | 02474271 | 1 MG / ML | SOLUTION · INTRAVENOUS | JUNO PHARMA CANADA INC. |
| METOPROLOL-L | 02442116 | 25 MG | TABLET · ORAL | SIVEM PHARMACEUTICALS ULC |
| METOPROLOL-L | 02442124 | 50 MG | TABLET · ORAL | SIVEM PHARMACEUTICALS ULC |
| METOPROLOL-L | 02442132 | 100 MG | TABLET · ORAL | SIVEM PHARMACEUTICALS ULC |
| PMS-METOPROLOL-L | 02230803 | 50 MG | TABLET · ORAL | PHARMASCIENCE INC |
| PMS-METOPROLOL-L | 02230804 | 100 MG | TABLET · ORAL | PHARMASCIENCE INC |
| PMS-METOPROLOL-L | 02248855 | 25 MG | TABLET · ORAL | PHARMASCIENCE INC |
| PRO-METOPROLOL | 02296713 | 25 MG | TABLET · ORAL | PRO DOC LIMITEE |
| PRO-METOPROLOL-L | 00648019 | 50 MG | TABLET · ORAL | PRO DOC LIMITEE |
| PRO-METOPROLOL-L | 00648027 | 100 MG | TABLET · ORAL | PRO DOC LIMITEE |
| RIVA-METOPROLOL-L | 02315300 | 25 MG | TABLET · ORAL | LABORATOIRE RIVA INC. |
| RIVA-METOPROLOL-L | 02315319 | 50 MG | TABLET · ORAL | LABORATOIRE RIVA INC. |
| RIVA-METOPROLOL-L | 02315327 | 100 MG | TABLET · ORAL | LABORATOIRE RIVA INC. |
5 more — full table
Prices — United States and England
| Source | Product as listed | Price | Unit / pack | Date |
|---|---|---|---|---|
| US NADAC | KAPSPARGO SPRINKLE 100 MG CAP | $2.29279 | per EA | 23 Sep 2026 |
| US NADAC | KAPSPARGO SPRINKLE 25 MG CAP | $1.88783 | per EA | 23 Sep 2026 |
| US NADAC | KAPSPARGO SPRINKLE 50 MG CAP | $1.88748 | per EA | 23 Sep 2026 |
| US NADAC | LOPRESSOR 10 MG/ML ORAL SOLN | $1.19616 | per ML | 23 Sep 2026 |
| US NADAC | LOPRESSOR 50 MG TABLET | $2.41634 | per EA | 21 Jan 2026 |
| US NADAC | METOPROLOL SUCC ER 100 MG TAB | $0.08496 | per EA | 7 Oct 2026 |
| US NADAC | METOPROLOL SUCC ER 200 MG TAB | $0.188 | per EA | 23 Sep 2026 |
| US NADAC | METOPROLOL SUCC ER 25 MG TAB | $0.04762 | per EA | 23 Sep 2026 |
| US NADAC | METOPROLOL SUCC ER 50 MG TAB | $0.05152 | per EA | 23 Sep 2026 |
| US NADAC | METOPROLOL TARTRATE 100 MG TAB | $0.02866 | per EA | 23 Sep 2026 |
| US NADAC | METOPROLOL TARTRATE 12.5 MG TB | $2.87431 | per EA | 23 Sep 2026 |
| US NADAC | METOPROLOL TARTRATE 25 MG TAB | $0.01587 | per EA | 23 Sep 2026 |
| NHS Drug Tariff | Metoprolol 100mg tablets | £1.80 | 28 tablet | 1 Oct 2026 |
| NHS Drug Tariff | Metoprolol 25mg tablets | £34.58 | 28 tablet | 1 Oct 2026 |
| NHS Drug Tariff | Metoprolol 50mg tablets | £1.47 | 28 tablet | 1 Oct 2026 |
NADAC: average price US retail pharmacies pay to buy the medicine. NHS Drug Tariff Part VIIIA: basic price reimbursed to pharmacies in England and Wales.
WHO WHO Model List of Essential Medicines (2025)
- 12.1. Antianginal medicines · core
Therapeutic equivalent to bisoprolol for Angina pectoris - 12.3. Antihypertensive medicines · core
Therapeutic equivalent to bisoprolol for Essential hypertension - 12.2. Antiarrhythmic medicines · core
Therapeutic equivalent to bisoprolol for Cardiac arrhythmia - 12.4. Medicines used in heart failure · core
Therapeutic equivalent to bisoprolol for Heart failure
Safety signals and safety-related labeling changes
- US FDA 22 Dec 2023 LOPRESSOR HCT — safety-related labeling change
Labeling sections changed: Contraindications; Warnings and Precautions; Adverse Reactions; Drug Interactions; Use in Specific Populations; Patient Counseling Information / Patient Information / Medication Guide - US FDA 22 Dec 2023 LOPRESSOR — safety-related labeling change
Labeling sections changed: Warnings and Precautions - US FDA 14 Apr 2023 KAPSPARGO SPRINKLE — safety-related labeling change
Labeling sections changed: Warnings and Precautions; Use in Specific Populations; Patient Counseling Information / Patient Information / Medication Guide - US FDA 10 Mar 2023 TOPROL-XL — safety-related labeling change
Labeling sections changed: Boxed Warning; Warnings and Precautions; Drug Interactions; Use in Specific Populations; Patient Counseling Information / Patient Information / Medication Guide - US FDA 14 Jan 2022 DUTOPROL — safety-related labeling change
Labeling sections changed: Boxed Warning; Warnings and Precautions; Adverse Reactions; Drug Interactions; Use in Specific Populations; Patient Counseling Information / Patient Information / Medication Guide
Values as published by each source: SFDA human drug list (4-2026, as published by the Council of Health Insurance; indications from the CHI Daman Drug Formulary), Drugs@FDA, EMA medicines data, Health Canada Drug Product Database (Open Government Licence – Canada), CMS NADAC, NHS Drug Tariff Part VIIIA (NHSBSA Copyright, Open Government Licence v3.0), WHO Model List of Essential Medicines (CC BY 3.0 IGO; regrouped by active substance, not created by WHO), EMA PRAC, US FDA safety-related labeling changes and MHRA Drug Safety Update (Open Government Licence v3.0). Sources and reuse. Not a substitute for the official registers or the product information.