Active substance
Penicillin g benzathine
- US FDA 6
- Health Canada 1
- Safety 3
US FDA United States — FDA approvals (Drugs@FDA)
| Product | Strength | Form · route | Applicant | Status | First approved |
|---|---|---|---|---|---|
| BICILLIN L-A | 600,000 UNITS/ML | injectable · injection | KING PHARMS LLC | Prescription | 27 Jun 1952 |
| BICILLIN | 300,000 UNITS/5ML | suspension · oral | WYETH AYERST | Discontinued | 22 Nov 1951 |
| BICILLIN L-A | 300,000 UNITS/ML | injectable · injection | KING PHARMS LLC | Discontinued | 27 Jun 1952 |
| PERMAPEN | 600,000 UNITS/ML | injectable · injection | CASPER PHARMA LLC | Discontinued | 16 Dec 1952 |
| BICILLIN L-A | 300,000 UNITS/ML | injectable · injection | WYETH AYERST | Discontinued | 31 Dec 1958 |
| BICILLIN | 200,000 UNITS | tablet · oral | WYETH AYERST | Discontinued |
Canada Canada — marketed products (Health Canada)
| Brand | DIN | Strength | Form · route | Company |
|---|---|---|---|---|
| BICILLIN L-A | 02291924 | 1200000 UNIT / 2 ML | SUSPENSION · INTRAMUSCULAR | PFIZER CANADA ULC |
Safety signals and safety-related labeling changes
- US FDA 25 Jun 2026 BICILLIN C-R — safety-related labeling change
Labeling sections changed: Warnings and Precautions; Adverse Reactions - US FDA 25 Jun 2026 BICILLIN C-R 900/300 — safety-related labeling change
Labeling sections changed: Warnings and Precautions; Adverse Reactions - US FDA 25 Jun 2026 BICILLIN L-A — safety-related labeling change
Labeling sections changed: Warnings and Precautions; Adverse Reactions
Values as published by each source: SFDA human drug list (4-2026, as published by the Council of Health Insurance; indications from the CHI Daman Drug Formulary), Drugs@FDA, EMA medicines data, Health Canada Drug Product Database (Open Government Licence – Canada), CMS NADAC, NHS Drug Tariff Part VIIIA (NHSBSA Copyright, Open Government Licence v3.0), WHO Model List of Essential Medicines (CC BY 3.0 IGO; regrouped by active substance, not created by WHO), EMA PRAC, US FDA safety-related labeling changes and MHRA Drug Safety Update (Open Government Licence v3.0). Sources and reuse. Not a substitute for the official registers or the product information.