Active substance
Pethidine
- SFDA 2
- US FDA 47
- Health Canada 1
- US price lines 1
- NHS prices 2
- Safety 3
SFDA Saudi Arabia — SFDA human drug list
| Trade name | Strength | Form · route | Pack | Public price | Type | Company | Status |
|---|---|---|---|---|---|---|---|
| PETHIDINE PETHIDINE 50 mg/ml injection BP | 50 mg/ml | Injection · Intramuscular and intravenous use | 10 Ampoule | SAR 30.10 | Generic · Prescription | MACARTHYS LABORATORIES Ltd T/A MARTINDALE PHARMACEUTICALS | Valid |
| PETHIDINE PETHIDINE 50 mg/ml injection BP | 50 mg/ml | Injection · Intramuscular and intravenous use | 10 Ampoule | SAR 30.10 | Generic · Prescription | MACARTHYS LABORATORIES Ltd T/A MARTINDALE PHARMACEUTICALS | Valid |
Indications — CHI Daman Drug Formulary
ACUTE PANCREATITIS-PAIN MANAGEMENT; ANESTHESIA; ENDOMETRIOSIS; POSTOPERATIVE PAIN
US FDA United States — FDA approvals (Drugs@FDA)
| Product | Strength | Form · route | Applicant | Status | First approved |
|---|---|---|---|---|---|
| DEMEROL | 25MG/ML; 50MG/ML; 75MG/ML; 100MG/ML | injectable · injection | HOSPIRA | Prescription | 10 Nov 1942 |
| MEPERIDINE HYDROCHLORIDE | 25MG/ML; 50MG/ML; 75MG/ML; 100MG/ML | injectable · injection | WEST-WARD PHARMS INT | Prescription | 26 Apr 1972 |
| MEPERIDINE HYDROCHLORIDE | 25MG/ML; 50MG/ML; 75MG/ML; 100MG/ML | injectable · injection | WEST-WARD PHARMS INT | Prescription | 22 Jan 1975 |
| MEPERIDINE HYDROCHLORIDE | 50MG/5ML | syrup · oral | HIKMA PHARMS | Prescription | 30 Jan 1985 |
| MEPERIDINE HYDROCHLORIDE PRESERVATIVE FREE | 10MG/ML | injectable · injection | WEST-WARD PHARMS INT | Prescription | 30 Jul 1993 |
| MEPERIDINE HYDROCHLORIDE | 50MG; 100MG | tablet · oral | EPIC PHARMA LLC | Prescription | 28 May 1999 |
| MEPERIDINE HYDROCHLORIDE | 50MG | tablet · oral | GENUS | Prescription | 24 Jun 2009 |
| DEMEROL | 50MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**; 100MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | tablet · oral | QUAGEN | Discontinued | 10 Nov 1942 |
| DEMEROL | 50MG/ML; 100MG/ML; 25MG/ML; 75MG/ML | injectable · injection | QUAGEN | Discontinued | 10 Nov 1942 |
| DEMEROL | 50MG/5ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | syrup · oral | QUAGEN | Discontinued | 10 Nov 1942 |
| MEPERIDINE HYDROCHLORIDE | 50MG | tablet · oral | WYETH AYERST | Discontinued | 31 Jul 1973 |
| MEPERIDINE HYDROCHLORIDE | 100MG/ML; 50MG/ML; 75MG/ML | injectable · injection | PARKE DAVIS | Discontinued | 19 May 1976 |
| MEPERIDINE HYDROCHLORIDE | 50MG; 100MG | tablet · oral | SUN PHARM INDUSTRIES | Discontinued | 15 Oct 1976 |
| MEPERIDINE HYDROCHLORIDE | 25MG/ML | injectable · injection | BAXTER HLTHCARE | Discontinued | 15 Jun 1984 |
| MEPERIDINE HYDROCHLORIDE | 50MG/ML | injectable · injection | BAXTER HLTHCARE | Discontinued | 15 Jun 1984 |
| MEPERIDINE HYDROCHLORIDE | 75MG/ML | injectable · injection | BAXTER HLTHCARE | Discontinued | 15 Jun 1984 |
| MEPERIDINE HYDROCHLORIDE | 100MG/ML | injectable · injection | BAXTER HLTHCARE | Discontinued | 15 Jun 1984 |
| MEPERIDINE HYDROCHLORIDE | 50MG | tablet · oral | BARR | Discontinued | 2 Jul 1984 |
| MEPERIDINE HYDROCHLORIDE PRESERVATIVE FREE | 10MG/ML | injectable · injection | ICU MEDICAL INC | Discontinued | 16 Aug 1984 |
| MEPERIDINE HYDROCHLORIDE | 100MG | tablet · oral | BARR | Discontinued | 19 Sep 1984 |
| MEPERIDINE HYDROCHLORIDE PRESERVATIVE FREE | 10MG/ML | injectable · injection | WATSON LABS | Discontinued | 17 Mar 1992 |
| MEPERIDINE HYDROCHLORIDE | 50MG/ML | injectable · injection | WATSON LABS | Discontinued | 17 Mar 1992 |
| MEPERIDINE HYDROCHLORIDE | 100MG/ML | injectable · injection | WATSON LABS | Discontinued | 17 Mar 1992 |
| MEPERIDINE HYDROCHLORIDE PRESERVATIVE FREE | 10MG/ML | injectable · injection | INTL MEDICATION | Discontinued | 30 Aug 1993 |
| MEPERIDINE HYDROCHLORIDE | 50MG; 100MG | tablet · oral | HIKMA PHARMS | Discontinued | 12 Mar 1997 |
22 more — full table
Canada Canada — marketed products (Health Canada)
| Brand | DIN | Strength | Form · route | Company |
|---|---|---|---|---|
| MEPERIDINE HYDROCHLORIDE INJECTION USP | 00725765 | 50 MG / ML | SOLUTION · INTRAVENOUS; SUBCUTANEOUS; INTRAMUSCULAR | SANDOZ CANADA INCORPORATED |
Prices — United States and England
| Source | Product as listed | Price | Unit / pack | Date |
|---|---|---|---|---|
| US NADAC | MEPERIDINE 50 MG/5 ML SOLUTION | $0.15672 | per ML | 23 Sep 2026 |
| NHS Drug Tariff | Pethidine 100mg/2ml solution for injection ampoules | £4.66 | 10 ampoule | 1 Oct 2026 |
| NHS Drug Tariff | Pethidine 50mg/1ml solution for injection ampoules | £5.11 | 10 ampoule | 1 Oct 2026 |
NADAC: average price US retail pharmacies pay to buy the medicine. NHS Drug Tariff Part VIIIA: basic price reimbursed to pharmacies in England and Wales.
Safety signals and safety-related labeling changes
- US FDA 22 Dec 2025 DEMEROL — safety-related labeling change
Labeling sections changed: Boxed Warning; Contraindications; Warnings and Precautions; Adverse Reactions; Drug Interactions; Use in Specific Populations; Patient Counseling Information / Patient Information / Medication Guide - US FDA 22 Dec 2025 DEMEROL — safety-related labeling change
Labeling sections changed: Boxed Warning; Contraindications; Warnings and Precautions; Adverse Reactions; Drug Interactions; Use in Specific Populations; Patient Counseling Information / Patient Information / Medication Guide - US FDA 22 Dec 2025 MEPERGAN — safety-related labeling change
Labeling sections changed: Boxed Warning; Contraindications; Warnings and Precautions; Adverse Reactions; Drug Interactions; Use in Specific Populations; Patient Counseling Information / Patient Information / Medication Guide
Values as published by each source: SFDA human drug list (4-2026, as published by the Council of Health Insurance; indications from the CHI Daman Drug Formulary), Drugs@FDA, EMA medicines data, Health Canada Drug Product Database (Open Government Licence – Canada), CMS NADAC, NHS Drug Tariff Part VIIIA (NHSBSA Copyright, Open Government Licence v3.0), WHO Model List of Essential Medicines (CC BY 3.0 IGO; regrouped by active substance, not created by WHO), EMA PRAC, US FDA safety-related labeling changes and MHRA Drug Safety Update (Open Government Licence v3.0). Sources and reuse. Not a substitute for the official registers or the product information.