Active substance
Pyrimethamine
- US FDA 5
- US price lines 1
- NHS prices 1
- WHO EML 1
- Safety 1
US FDA United States — FDA approvals (Drugs@FDA)
| Product | Strength | Form · route | Applicant | Status | First approved |
|---|---|---|---|---|---|
| DARAPRIM | 25MG | tablet · oral | TILDE SCIENCES | Prescription | 23 Jan 1953 |
| PYRIMETHAMINE | 25MG | tablet · oral | SANALUZ | Prescription | 28 Feb 2020 |
| PYRIMETHAMINE | 25MG | tablet · oral | TEVA PHARMS | Prescription | 13 Aug 2021 |
| PYRIMETHAMINE | 25MG | tablet · oral | AUROBINDO PHARMA LTD | Prescription | 25 Oct 2022 |
| PYRIMETHAMINE | 25MG | tablet · oral | ALVOGEN | Discontinued | 27 Jul 2021 |
Prices — United States and England
| Source | Product as listed | Price | Unit / pack | Date |
|---|---|---|---|---|
| US NADAC | PYRIMETHAMINE 25 MG TABLET | $137.00879 | per EA | 20 May 2026 |
| NHS Drug Tariff | Pyrimethamine 25mg tablets | £13.00 | 30 tablet | 1 Oct 2026 |
NADAC: average price US retail pharmacies pay to buy the medicine. NHS Drug Tariff Part VIIIA: basic price reimbursed to pharmacies in England and Wales.
WHO WHO Model List of Essential Medicines (2025)
- 6.5.4. Antipneumocystosis and antitoxoplasmosis medicines · core
Toxoplasmosis
Oral > Solid: 25 mg
Safety signals and safety-related labeling changes
- US FDA 21 Jun 2017 DARAPRIM — safety-related labeling change
Labeling sections changed: Warnings and Precautions; Adverse Reactions
Combinations containing Pyrimethamine
Values as published by each source: SFDA human drug list (4-2026, as published by the Council of Health Insurance; indications from the CHI Daman Drug Formulary), Drugs@FDA, EMA medicines data, Health Canada Drug Product Database (Open Government Licence – Canada), CMS NADAC, NHS Drug Tariff Part VIIIA (NHSBSA Copyright, Open Government Licence v3.0), WHO Model List of Essential Medicines (CC BY 3.0 IGO; regrouped by active substance, not created by WHO), EMA PRAC, US FDA safety-related labeling changes and MHRA Drug Safety Update (Open Government Licence v3.0). Sources and reuse. Not a substitute for the official registers or the product information.