Active substance
Trypan blue
- US FDA 2
- Health Canada 1
- Safety 2
US FDA United States — FDA approvals (Drugs@FDA)
| Product | Strength | Form · route | Applicant | Status | First approved |
|---|---|---|---|---|---|
| VISIONBLUE | 0.06% | solution · ophthalmic | DORC | Prescription | 16 Dec 2004 |
| MEMBRANEBLUE | 0.15% | solution · ophthalmic | DORC | Discontinued | 20 Feb 2009 |
Canada Canada — marketed products (Health Canada)
| Brand | DIN | Strength | Form · route | Company |
|---|---|---|---|---|
| VISIONBLUE | 02279525 | 0.06 % | SOLUTION · INTRAOCULAR | DUTCH OPHTHALMIC RESEARCH CENTER INTERNATIONAL BV |
Safety signals and safety-related labeling changes
- US FDA 17 Nov 2025 MEMBRANEBLUE — safety-related labeling change
Labeling sections changed: Warnings and Precautions; Use in Specific Populations - US FDA 18 Dec 2023 VISIONBLUE — safety-related labeling change
Labeling sections changed: Use in Specific Populations
Values as published by each source: SFDA human drug list (4-2026, as published by the Council of Health Insurance; indications from the CHI Daman Drug Formulary), Drugs@FDA, EMA medicines data, Health Canada Drug Product Database (Open Government Licence – Canada), CMS NADAC, NHS Drug Tariff Part VIIIA (NHSBSA Copyright, Open Government Licence v3.0), WHO Model List of Essential Medicines (CC BY 3.0 IGO; regrouped by active substance, not created by WHO), EMA PRAC, US FDA safety-related labeling changes and MHRA Drug Safety Update (Open Government Licence v3.0). Sources and reuse. Not a substitute for the official registers or the product information.