Regulatory PathRegulatory requirements compared

Active substances

Diphenhydramine + Paracetamol

Open in the medicines table

SFDA Saudi Arabia — SFDA human drug list

Trade nameStrengthForm · routePackPublic priceTypeCompanyStatus
ADOL PM 325MG-25MG CAPLET325,25 mg,mgCaplet · Oral use24 BlisterSAR 9.30NCE · OTCGulf Pharmaceutical Industries (Julphar)Valid
PANADOL NIGHT CAPLET500,25 mg,mgTablet · Oral use20 BlisterSAR 11.60Generic · OTCGLAXOSMITHKLINE (GSK)Valid

Canada Canada — marketed products (Health Canada)

BrandDINStrengthForm · routeCompany
ACETAMINOPHEN WITH ANTIHISTAMINE NIGHTTIME02238183500 MG; 25 MGTABLET · ORALLABORATOIRES TRIANON INC.
EXTRA STRENGTH TYLENOL NIGHTTIME0238561925 MG; 500 MGTABLET · ORALKENVUE CANADA INC.
NEOCITRAN EXTRA STRENGTH COLD & COUGH NIGHT02552531650 MG / SACHET; 25 MG / SACHETPOWDER FOR SOLUTION · ORALHALEON CANADA ULC
NYQUIL HOT REMEDY0255438025 MG / SACHET; 650 MG / SACHETPOWDER FOR SOLUTION · ORALPROCTER & GAMBLE INC

Prices — United States and England

SourceProduct as listedPriceUnit / packDate
NHS Drug TariffParacetamol 500mg / Diphenhydramine 25mg tablets£3.6820 tablet1 Oct 2026

NADAC: average price US retail pharmacies pay to buy the medicine. NHS Drug Tariff Part VIIIA: basic price reimbursed to pharmacies in England and Wales.

Components

Values as published by each source: SFDA human drug list (4-2026, as published by the Council of Health Insurance; indications from the CHI Daman Drug Formulary), Drugs@FDA, EMA medicines data, Health Canada Drug Product Database (Open Government Licence – Canada), CMS NADAC, NHS Drug Tariff Part VIIIA (NHSBSA Copyright, Open Government Licence v3.0), WHO Model List of Essential Medicines (CC BY 3.0 IGO; regrouped by active substance, not created by WHO), EMA PRAC, US FDA safety-related labeling changes and MHRA Drug Safety Update (Open Government Licence v3.0). Sources and reuse. Not a substitute for the official registers or the product information.