Active substance
Diphenhydramine
- SFDA 4
- US FDA 95
- Health Canada 52
- US price lines 20
- NHS prices 4
- Safety 3
SFDA Saudi Arabia — SFDA human drug list
| Trade name | Strength | Form · route | Pack | Public price | Type | Company | Status |
|---|---|---|---|---|---|---|---|
| AMYDRAMINE II SUGAR FREE SYRUP | 2.5 mg/ml | Syrup · Oral use | 1 Bottle | SAR 7.15 | Generic · OTC | Gulf Pharmaceutical Industries (Julphar) | Valid |
| EXYLIN SYRUP 14MG-5ML | 2.8 mg/ml | Syrup · Oral use | 1 Bottle | SAR 7.70 | Generic · OTC | SPIMACO ADDWAEIH | Valid |
| EZIPECT 12.5MG-5ML SYRUP | 2.5 mg/ml | Syrup · Oral use | 1 Bottle | SAR 7.25 | Generic · OTC | Tabuk Pharmaceutical Manufacturing Company | Valid |
| BENADRYL ELIXIR 12.5MG-5ML | 2.5 mg/ml | Syrup · Oral use | 1 Bottle | SAR 8.60 | Generic · OTC | PARK-DAVIS | Withdrawn by MAH · Not Marketed |
Indications — CHI Daman Drug Formulary
ACUTE COUGH; ALLERGIC CONJUCTIVITIS (AC); ANESTHESIA; BACTERIAL TONSILLOPHARYNGITIS TREATMENT AND PREVENTION; POLYCYTHEMIA VERA - PRURITUS; RENAL TRANSPLANT; SCHIZOPHRENIA; VERTIGO - MOTION SICKNESS
US FDA United States — FDA approvals (Drugs@FDA)
| Product | Strength | Form · route | Applicant | Status | First approved |
|---|---|---|---|---|---|
| DIPHENHYDRAMINE HYDROCHLORIDE | 50MG/ML | injectable · injection | WEST-WARD PHARMS INT | Prescription | 27 Nov 1972 |
| DIPHENHYDRAMINE HYDROCHLORIDE | 12.5MG/5ML | elixir · oral | PHARM ASSOC | Prescription | 10 Feb 1982 |
| DIPHENHYDRAMINE HYDROCHLORIDE | 50MG/ML | injectable · injection | APP PHARMS | Prescription | 28 May 2002 |
| DIPHENHYDRAMINE HYDROCHLORIDE PRESERVATIVE FREE | 50MG/ML | injectable · injection | FRESENIUS KABI USA | Prescription | 26 Mar 2013 |
| DIPHENHYDRAMINE HYDROCHLORIDE | 50MG/ML | injectable · injection | MICRO LABS | Prescription | 22 Aug 2018 |
| DIPHENHYDRAMINE HYDROCHLORIDE | 50MG/ML | injectable · injection | GLAND | Prescription | 20 Mar 2024 |
| DIPHENHYDRAMINE HYDROCHLORIDE | 50MG/ML | injectable · injection | AVET LIFESCIENCES | Prescription | 24 Jun 2025 |
| DIPHENHYDRAMINE HYDROCHLORIDE | 50MG/ML | injectable · injection | MICRO LABS | Prescription | 22 Aug 2025 |
| DIPHENHYDRAMINE HYDROCHLORIDE | 50MG/ML | injectable · injection | AVET LIFESCIENCES | Prescription | 14 Nov 2025 |
| DIPHENHYDRAMINE HYDROCHLORIDE | 12.5MG/5ML | elixir · oral | ANNORA PHARMA | Prescription | 17 Jun 2026 |
| BENADRYL | 50MG; 25MG | capsule · oral | MCNEIL CONS | Discontinued | 4 Mar 1946 |
| BENADRYL | 12.5MG/5ML | elixir · oral | MCNEIL CONS | Discontinued | 4 Mar 1946 |
| BENADRYL | 10MG/ML; 50MG/ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | injectable · injection | MCNEIL CONS | Discontinued | 6 Mar 1947 |
| BENADRYL PRESERVATIVE FREE | 50MG/ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | injectable · injection | MCNEIL CONS | Discontinued | 30 Dec 1957 |
| DIPHENHYDRAMINE HYDROCHLORIDE | 25MG; 50MG | capsule · oral | IVAX SUB TEVA PHARMS | Discontinued | 9 May 1972 |
| DIPHENHYDRAMINE HYDROCHLORIDE | 50MG; 25MG | capsule · oral | ALRA | Discontinued | 31 May 1972 |
| DIPHENHYDRAMINE HYDROCHLORIDE | 50MG/ML | injectable · injection | WYETH AYERST | Discontinued | 7 Aug 1972 |
| DIPHENHYDRAMINE HYDROCHLORIDE | 50MG | capsule · oral | HERITAGE PHARMA | Discontinued | 24 Aug 1972 |
| DIPHENHYDRAMINE HYDROCHLORIDE | 50MG | capsule · oral | HERITAGE PHARMA | Discontinued | 27 Sep 1972 |
| DIPHENHYDRAMINE HYDROCHLORIDE | 25MG; 50MG | capsule · oral | FOSUN PHARMA | Discontinued | 3 Nov 1972 |
| DIPHENHYDRAMINE HYDROCHLORIDE | 12.5MG/5ML | elixir · oral | ROXANE | Discontinued | 20 Dec 1972 |
| DIPHENHYDRAMINE HYDROCHLORIDE | 25MG; 50MG | capsule · oral | MK LABS | Discontinued | 12 Jan 1973 |
| DIPHENHYDRAMINE HYDROCHLORIDE | 12.5MG/5ML | elixir · oral | MK LABS | Discontinued | 12 Jan 1973 |
| DIPHENHYDRAMINE HYDROCHLORIDE | 25MG | capsule · oral | WATSON LABS | Discontinued | 28 Feb 1973 |
| DIPHENHYDRAMINE HYDROCHLORIDE | 50MG | capsule · oral | WHITEWORTH TOWN PLSN | Discontinued | 13 Aug 1973 |
70 more — full table
Canada Canada — marketed products (Health Canada)
| Brand | DIN | Strength | Form · route | Company |
|---|---|---|---|---|
| ALLERGY FORMULA | 02229492 | 25 MG | TABLET · ORAL | VITA HEALTH PRODUCTS INC |
| ALLERGY FORMULA | 02465108 | 12.5 MG / 5 ML | SOLUTION · ORAL | LSL MEDPLUS INC |
| ALLERGY FORMULA CAPLETS | 02141728 | 25 MG | TABLET · ORAL | PERRIGO INTERNATIONAL |
| ALLERGY FORMULA CAPLETS | 02479710 | 25 MG | TABLET · ORAL | SIGMA LIFE SCIENCES INC. |
| ALLERGY FORMULA EXTRA STRENGTH | 02490943 | 50 MG | TABLET · ORAL | VITA HEALTH PRODUCTS INC |
| ALLERGY FORMULA LIQUID CAPSULES | 02306352 | 25 MG | CAPSULE · ORAL | VITA HEALTH PRODUCTS INC |
| ALLERNIX | 02097583 | 25 MG | TABLET · ORAL | TEVA CANADA LIMITED |
| ALLERNIX EXTRA STRENGTH | 02097575 | 50 MG | TABLET · ORAL | TEVA CANADA LIMITED |
| ANTI-ITCH CREAM | 02247560 | 2 % | CREAM · TOPICAL | TARO PHARMACEUTICALS INC |
| BENADRYL ALLERGY | 02017849 | 25 MG | TABLET · ORAL | KENVUE CANADA INC. |
| BENADRYL ALLERGY LIQUID | 02019736 | 12.5 MG / 5 ML | SOLUTION · ORAL | KENVUE CANADA INC. |
| BENADRYL ALLERGY LIQUIGELS | 02304252 | 25 MG | CAPSULE · ORAL | KENVUE CANADA INC. |
| BENYLIN FOR CHILDREN COUGH NIGHT | 02248858 | 6.25 MG / 5 ML | SOLUTION · ORAL | KENVUE CANADA INC. |
| BENYLIN SLEEP TIME | 02248859 | 12.5 MG / 5 ML | SOLUTION · ORAL | KENVUE CANADA INC. |
| CHILDREN'S ALLERGY FORMULA RAPID MELTS | 02505649 | 12.5 MG | TABLET (ORALLY-DISINTEGRATING) · ORAL | LSL MEDPLUS INC |
| CHILDREN'S BENADRYL ALLERGY LIQUID | 02019698 | 6.25 MG / 5 ML | SOLUTION · ORAL | KENVUE CANADA INC. |
| CHILDREN'S CLEAR ALLERGY FORMULA | 02478242 | 6.25 MG / 5 ML | SOLUTION · ORAL | LSL MEDPLUS INC |
| DIPHENHYDRAMINE HYDROCHLORIDE ELIXIR USP | 02298503 | 12.5 MG / 5 ML | ELIXIR · ORAL | JAMP PHARMA CORPORATION |
| DIPHENHYDRAMINE HYDROCHLORIDE INJECTION USP | 00596612 | 50 MG / ML | LIQUID · INTRAMUSCULAR; INTRAVENOUS | SANDOZ CANADA INCORPORATED |
| DIPHENHYDRAMINE HYDROCHLORIDE INJECTION, USP | 02369567 | 50 MG / ML | SOLUTION · INTRAMUSCULAR; INTRAVENOUS | FRESENIUS KABI CANADA LTD |
| DIPHENIST | 02219336 | 50 MG / ML | LIQUID · INTRAVENOUS; INTRAMUSCULAR | OMEGA LABORATORIES LIMITED |
| DORMIPHEN EXTRA-FORT CAPSULE | 00489867 | 50 MG | CAPSULE · ORAL | LABORATOIRE LALCO INC. |
| DORMIPHEN EXTRA-FORT COMPRIME | 02237789 | 50 MG | TABLET · ORAL | LABORATOIRE LALCO INC. |
| EXTRA STRENGTH ALLERGY FORMULA LIQUID CAPSULES | 02321270 | 50 MG | CAPSULE · ORAL | VITA HEALTH PRODUCTS INC |
| EXTRA STRENGTH BENADRYL ALLERGY | 02470144 | 50 MG | TABLET · ORAL | KENVUE CANADA INC. |
27 more — full table
Prices — United States and England
| Source | Product as listed | Price | Unit / pack | Date |
|---|---|---|---|---|
| US NADAC | DIPHENHYDRAMINE 12.5 MG/5 ML | $0.01744 | per ML | 23 Sep 2026 |
| US NADAC | DIPHENHYDRAMINE 12.5 MG/5 ML | $0.01921 | per ML | 23 Sep 2026 |
| US NADAC | DIPHENHYDRAMINE 25 MG CAPSULE | $0.05336 | per EA | 23 Sep 2026 |
| US NADAC | DIPHENHYDRAMINE 25 MG TABLET | $0.03697 | per EA | 23 Sep 2026 |
| US NADAC | DIPHENHYDRAMINE 50 MG CAPSULE | $0.02976 | per EA | 23 Sep 2026 |
| US NADAC | DIPHENHYDRAMINE 50 MG/ML VIAL | $0.89801 | per ML | 23 Sep 2026 |
| US NADAC | DIPHENHYDRAMINE 50 MG/ML VIAL | $1.0542 | per ML | 23 Sep 2026 |
| US NADAC | FT SLEEP AID 25 MG TABLET | $0.11579 | per EA | 23 Sep 2026 |
| US NADAC | FT SLEEP AID 50 MG SOFTGEL | $0.11141 | per EA | 23 Sep 2026 |
| US NADAC | GNP NIGHTTIME SLEEP AID 50 MG | $0.11141 | per EA | 23 Sep 2026 |
| US NADAC | GNP SLEEP AID 25 MG CAPLET | $0.05997 | per EA | 23 Sep 2026 |
| US NADAC | GNP SLEEP AID 50 MG/30 ML LIQ | $0.00864 | per ML | 23 Sep 2026 |
| NHS Drug Tariff | Diphenhydramine 10mg/5ml oral solution | £26.00 | 150 ml | 1 Oct 2026 |
| NHS Drug Tariff | Diphenhydramine 2% cream | £4.89 | 25 gram | 1 Oct 2026 |
| NHS Drug Tariff | Diphenhydramine 25mg tablets | £2.87 | 20 tablet | 1 Oct 2026 |
| NHS Drug Tariff | Diphenhydramine 50mg tablets | £4.36 | 20 tablet | 1 Oct 2026 |
NADAC: average price US retail pharmacies pay to buy the medicine. NHS Drug Tariff Part VIIIA: basic price reimbursed to pharmacies in England and Wales.
Safety signals and safety-related labeling changes
- US FDA 21 Feb 2023 ADVIL PM — safety-related labeling change
Labeling sections changed: Warnings and Precautions - US FDA 8 Feb 2022 ALEVE PM — safety-related labeling change
Labeling sections changed: Warnings and Precautions - US FDA 11 Jan 2022 ADVIL PM — safety-related labeling change
Labeling sections changed: Warnings and Precautions
Combinations containing Diphenhydramine
- Ammonium chloride + diphenhydramine
- Diphenhydramine + ibuprofen
- Diphenhydramine + menthol
- Diphenhydramine + naproxen
- Diphenhydramine + paracetamol
- Diphenhydramine + sodium citrate
- Ammonium chloride + diphenhydramine + sodium citrate
- Dextromethorphan + diphenhydramine + pseudoephedrine
- Diphenhydramine + menthol + sodium citrate
- Diphenhydramine + paracetamol + pseudoephedrine
Values as published by each source: SFDA human drug list (4-2026, as published by the Council of Health Insurance; indications from the CHI Daman Drug Formulary), Drugs@FDA, EMA medicines data, Health Canada Drug Product Database (Open Government Licence – Canada), CMS NADAC, NHS Drug Tariff Part VIIIA (NHSBSA Copyright, Open Government Licence v3.0), WHO Model List of Essential Medicines (CC BY 3.0 IGO; regrouped by active substance, not created by WHO), EMA PRAC, US FDA safety-related labeling changes and MHRA Drug Safety Update (Open Government Licence v3.0). Sources and reuse. Not a substitute for the official registers or the product information.