Active substances
Estradiol + Medroxyprogesterone
- US FDA 1
- UK MHRA 3
- NHS prices 3
- WHO EML 1
US FDA United States — FDA approvals (Drugs@FDA)
| Product | Strength | Form · route | Applicant | Status | First approved |
|---|---|---|---|---|---|
| LUNELLE | 5MG/0.5ML;25MG/0.5ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | injectable · intramuscular | PHARMACIA AND UPJOHN | Discontinued | 5 Oct 2000 |
UK MHRA United Kingdom — marketing authorisations
| Product | Authorisation | Holder | Legal status |
|---|---|---|---|
| INDIVINA 1MG/2.5MG TABLETS | PL 27925/0011 | ORION CORPORATION | POM |
| INDIVINA 1MG/5MG TABLETS | PL 27925/0012 | ORION CORPORATION | POM |
| INDIVINA 2MG/5MG TABLETS | PL 27925/0013 | ORION CORPORATION | POM |
Prices — United States and England
| Source | Product as listed | Price | Unit / pack | Date |
|---|---|---|---|---|
| NHS Drug Tariff | Estradiol valerate 1mg / Medroxyprogesterone 2.5mg tablets | £20.58 | 84 tablet | 1 Oct 2026 |
| NHS Drug Tariff | Estradiol valerate 1mg / Medroxyprogesterone 5mg tablets | £20.58 | 84 tablet | 1 Oct 2026 |
| NHS Drug Tariff | Estradiol valerate 2mg / Medroxyprogesterone 5mg tablets | £20.58 | 84 tablet | 1 Oct 2026 |
NADAC: average price US retail pharmacies pay to buy the medicine. NHS Drug Tariff Part VIIIA: basic price reimbursed to pharmacies in England and Wales.
WHO WHO Model List of Essential Medicines (2025)
- 22.1.2. Injectable hormonal contraceptives · core
Contact with health services for reasons associated with reproduction
Parenteral > General injections > IM: 5 mg + 25 mg
Components
Values as published by each source: SFDA human drug list (4-2026, as published by the Council of Health Insurance; indications from the CHI Daman Drug Formulary), Drugs@FDA, EMA medicines data, Health Canada Drug Product Database (Open Government Licence – Canada), MHRA category lists of UK marketing authorisations (Open Government Licence v3.0), CMS NADAC, NHS Drug Tariff Part VIIIA (NHSBSA Copyright, Open Government Licence v3.0), WHO Model List of Essential Medicines (CC BY 3.0 IGO; regrouped by active substance, not created by WHO), EMA PRAC, US FDA safety-related labeling changes and MHRA Drug Safety Update (Open Government Licence v3.0). Sources and reuse. Not a substitute for the official registers or the product information.