Active substance
Estradiol
- SFDA 4
- US FDA 83
- Health Canada 22
- US price lines 61
- NHS prices 24
- Safety 30
SFDA Saudi Arabia — SFDA human drug list
| Trade name | Strength | Form · route | Pack | Public price | Type | Company | Status |
|---|---|---|---|---|---|---|---|
| ESTRADERM MX-100 | 8 mg | Transdermal patch · Topical | 6 Box | SAR 39.05 | NCE · Prescription | NOVARTIS | Withdrawn by MAH · Not Marketed |
| ESTRADERM MX-25 | 2 mg | Transdermal patch · Topical | 6 Box | SAR 18.65 | NCE · Prescription | NOVARTIS | Withdrawn by MAH · Not Marketed |
| ESTRADERM MX-50 | 4 mg | Transdermal patch · Topical | 6 Box | SAR 26.95 | NCE · Prescription | NOVARTIS | Withdrawn by MAH · Not Marketed |
| VAGIFEM 25MICROGRAM- VAGINAL TAB | 25 µg | Tablet · Vaginal use | 15 Applicator | SAR 32.25 | NCE · Prescription | NOVO NORDISK | Withdrawn by MAH · Not Marketed |
US FDA United States — FDA approvals (Drugs@FDA)
| Product | Strength | Form · route | Applicant | Status | First approved |
|---|---|---|---|---|---|
| DELESTROGEN | 10MG/ML; 20MG/ML | injectable · injection | PH HEALTH | Prescription | 15 Jul 1954 |
| DEPO-ESTRADIOL | 5MG/ML | injectable · injection | PFIZER | Prescription | 15 Aug 1979 |
| ESTRACE | 0.01% | cream · vaginal | ABBVIE | Prescription | 31 Jan 1984 |
| CLIMARA | 0.05MG/24HR; 0.1MG/24HR; 0.075MG/24HR; 0.025MG/24HR; 0.0375MG/24HR; 0.06MG/24HR | film, extended release · transdermal | BAYER HLTHCARE | Prescription | 22 Dec 1994 |
| MENOSTAR | 0.014MG/24HR | film, extended release · transdermal | BAYER HLTHCARE | Prescription | 22 Dec 1994 |
| ESTRING | 0.0075MG/24HR | insert, extended release · vaginal | PFIZER | Prescription | 26 Apr 1996 |
| VIVELLE-DOT | 0.0375MG/24HR; 0.05MG/24HR; 0.075MG/24HR; 0.1MG/24HR; 0.025MG/24HR | system · transdermal | SANDOZ | Prescription | 31 Jul 1996 |
| ESTRADIOL | 0.5MG; 1MG; 2MG | tablet · oral | BARR LABS INC | Prescription | 22 Oct 1997 |
| ESTRADIOL | 0.5MG; 1MG; 2MG | tablet · oral | EPIC PHARMA LLC | Prescription | 29 Dec 1998 |
| VAGIFEM | 10MCG | tablet · vaginal | NOVO NORDISK INC | Prescription | 26 Mar 1999 |
| ESTRADIOL | 0.1MG/24HR; 0.075MG/24HR; 0.025MG/24HR; 0.0375MG/24HR; 0.06MG/24HR; 0.05MG/24HR | film, extended release · transdermal | MYLAN TECHNOLOGIES | Prescription | 24 Feb 2000 |
| ESTRADIOL | 0.05MG/24HR | film, extended release · transdermal | MYLAN TECHNOLOGIES | Prescription | 24 Feb 2000 |
| VIVELLE | 0.05MG/24HR; 0.1MG/24HR | film, extended release · transdermal | NOVARTIS | Prescription | 16 Aug 2000 |
| ALORA | N/A | film, extended release · transdermal | WATSON LABS | Prescription | 5 Apr 2002 |
| FEMRING | EQ 0.05MG BASE/24HR; EQ 0.1MG BASE/24HR | insert, extended release · vaginal | MILLICENT MFG PR | Prescription | 20 Mar 2003 |
| ESTROGEL | 0.06% (1.25GM/ACTIVATION) | gel, metered · transdermal | ASCEND THERAPS US | Prescription | 9 Feb 2004 |
| MENOSTAR | 0.014MG/24HR | system · transdermal | BAYER HLTHCARE | Prescription | 8 Jun 2004 |
| ELESTRIN | 0.06% (0.87GM/ACTIVATION) | gel, metered · transdermal | VIATRIS | Prescription | 15 Dec 2006 |
| DIVIGEL | 0.1% (0.25GM/PACKET); 0.1% (0.5GM/PACKET); 0.1% (1GM/PACKET); 0.1% (0.75GM/PACKET); 0.1% (1.25GM/PACKET) | gel · transdermal | VERTICAL PHARMS | Prescription | 4 Jun 2007 |
| EVAMIST | 1.53MG/SPRAY | spray · transdermal | PADAGIS US | Prescription | 27 Jul 2007 |
| ESTRADIOL VALERATE | 20MG/ML; 40MG/ML | injectable · injection | AM REGENT | Prescription | 19 Jan 2010 |
| MINIVELLE | 0.0375MG/24HR; 0.075MG/24HR; 0.05MG/24HR; 0.1MG/24HR; 0.025MG/24HR | film, extended release · transdermal | NOVEN | Prescription | 29 Oct 2012 |
| ESTRADIOL | 0.025MG/DAY; 0.0375MG/DAY; 0.05MG/DAY; 0.075MG/DAY; 0.1MG/DAY | system · transdermal | MYLAN PHARMS INC | Prescription | 19 Dec 2014 |
| ESTRADIOL | 0.025MG/24HR; 0.0375MG/24HR; 0.05MG/24HR; 0.075MG/24HR; 0.1MG/24HR | system · transdermal | MYLAN TECHNOLOGIES | Prescription | 19 Dec 2014 |
| ESTRADIOL | 10MCG | tablet · vaginal | AMNEAL PHARMS | Prescription | 29 May 2015 |
58 more — full table
Canada Canada — marketed products (Health Canada)
| Brand | DIN | Strength | Form · route | Company |
|---|---|---|---|---|
| CLIMARA 25 | 02247499 | 25 MCG / 24 HOUR | PATCH · TRANSDERMAL | BAYER INC |
| CLIMARA 50 | 02231509 | 50 MCG / 24 HOUR | PATCH · TRANSDERMAL | BAYER INC |
| CLIMARA 75 | 02247500 | 75 MCG / 24 HOUR | PATCH · TRANSDERMAL | BAYER INC |
| DIVIGEL | 02424835 | 0.1 % | GEL · TRANSDERMAL | SEARCHLIGHT PHARMA INC |
| DIVIGEL | 02424843 | 0.1 % | GEL · TRANSDERMAL | SEARCHLIGHT PHARMA INC |
| DIVIGEL | 02424924 | 0.1 % | GEL · TRANSDERMAL | SEARCHLIGHT PHARMA INC |
| ESTRADOT 100 | 02244002 | 100 MCG / 24 HOUR | PATCH · TRANSDERMAL | SANDOZ CANADA INCORPORATED |
| ESTRADOT 25 | 02245676 | 25 MCG / 24 HOUR | PATCH · TRANSDERMAL | SANDOZ CANADA INCORPORATED |
| ESTRADOT 37.5 | 02243999 | 37.5 MCG / 24 HOUR | PATCH · TRANSDERMAL | SANDOZ CANADA INCORPORATED |
| ESTRADOT 50 | 02244000 | 50 MCG / 24 HOUR | PATCH · TRANSDERMAL | SANDOZ CANADA INCORPORATED |
| ESTRADOT 75 | 02244001 | 75 MCG / 24 HOUR | PATCH · TRANSDERMAL | SANDOZ CANADA INCORPORATED |
| ESTRING | 02168898 | 2 MG | RING (SLOW-RELEASE) · VAGINAL | PFIZER CANADA ULC |
| ESTROGEL | 02238704 | 0.06 % / W/W | GEL · TRANSDERMAL | ORGANON CANADA INC. |
| IMVEXXY | 02503689 | 4 MCG / INSERT | INSERT · VAGINAL | KNIGHT THERAPEUTICS INC. |
| IMVEXXY | 02503697 | 10 MCG / INSERT | INSERT · VAGINAL | KNIGHT THERAPEUTICS INC. |
| LUPIN-ESTRADIOL | 02449048 | 0.5 MG | TABLET · ORAL | LUPIN PHARMA CANADA LIMITED |
| LUPIN-ESTRADIOL | 02449056 | 1 MG | TABLET · ORAL | LUPIN PHARMA CANADA LIMITED |
| LUPIN-ESTRADIOL | 02449064 | 2 MG | TABLET · ORAL | LUPIN PHARMA CANADA LIMITED |
| SANDOZ ESTRADIOL DERM 100 | 02246969 | 100 MCG / 24 HOUR | PATCH · TRANSDERMAL | SANDOZ CANADA INCORPORATED |
| SANDOZ ESTRADIOL DERM 50 | 02246967 | 50 MCG / 24 HOUR | PATCH · TRANSDERMAL | SANDOZ CANADA INCORPORATED |
| SANDOZ ESTRADIOL DERM 75 | 02246968 | 75 MCG / 24 HOUR | PATCH · TRANSDERMAL | SANDOZ CANADA INCORPORATED |
| VAGIFEM 10 | 02325462 | 10 MCG | VAGINAL TABLET · VAGINAL | NOVO NORDISK CANADA INC |
Prices — United States and England
| Source | Product as listed | Price | Unit / pack | Date |
|---|---|---|---|---|
| US NADAC | CLIMARA 0.025 MG/DAY PATCH | $18.22764 | per EA | 23 Sep 2026 |
| US NADAC | CLIMARA 0.0375 MG/DAY PATCH | $18.29817 | per EA | 23 Sep 2026 |
| US NADAC | CLIMARA 0.05 MG/DAY PATCH | $18.25678 | per EA | 23 Sep 2026 |
| US NADAC | CLIMARA 0.06 MG/DAY PATCH | $18.14596 | per EA | 23 Sep 2026 |
| US NADAC | CLIMARA 0.075 MG/DAY PATCH | $18.25087 | per EA | 23 Sep 2026 |
| US NADAC | CLIMARA 0.1 MG/DAY PATCH | $18.27935 | per EA | 23 Sep 2026 |
| US NADAC | DELESTROGEN 100 MG/5 ML VIAL | $35.75275 | per ML | 23 Sep 2026 |
| US NADAC | DELESTROGEN 50 MG/5 ML VIAL | $25.50486 | per ML | 23 Sep 2026 |
| US NADAC | DEPO-ESTRADIOL 5 MG/ML VIAL | $51.90841 | per ML | 1 Jul 2026 |
| US NADAC | DIVIGEL 0.25 MG GEL PACKET | $5.388 | per EA | 23 Sep 2026 |
| US NADAC | DIVIGEL 0.5 MG GEL PACKET | $5.39183 | per EA | 23 Sep 2026 |
| US NADAC | DIVIGEL 0.75 MG GEL PACKET | $5.40611 | per EA | 23 Sep 2026 |
| NHS Drug Tariff | Estradiol 0.06% transdermal gel (750microgram per actuation) | £9.15 | 80 gram | 1 Oct 2026 |
| NHS Drug Tariff | Estradiol 1.53mg/dose transdermal spray | £6.90 | 56 dose | 1 Oct 2026 |
| NHS Drug Tariff | Estradiol 1.53mg/dose transdermal spray | £20.70 | 168 dose | 1 Oct 2026 |
| NHS Drug Tariff | Estradiol 100micrograms/24hours transdermal patches | £7.28 | 4 patch | 1 Oct 2026 |
| NHS Drug Tariff | Estradiol 100micrograms/24hours transdermal patches | £5.09 | 8 patch | 1 Oct 2026 |
| NHS Drug Tariff | Estradiol 100micrograms/24hours transdermal patches | £19.99 | 24 patch | 1 Oct 2026 |
| NHS Drug Tariff | Estradiol 10microgram pessaries | £11.56 | 24 pessary | 1 Oct 2026 |
| NHS Drug Tariff | Estradiol 1mg tablets | £5.06 | 84 tablet | 1 Oct 2026 |
| NHS Drug Tariff | Estradiol 1mg transdermal gel sachets | £8.50 | 28 sachet | 1 Oct 2026 |
| NHS Drug Tariff | Estradiol 1mg transdermal gel sachets | £27.62 | 91 sachet | 1 Oct 2026 |
| NHS Drug Tariff | Estradiol 25micrograms/24hours transdermal patches | £4.07 | 8 patch | 1 Oct 2026 |
| NHS Drug Tariff | Estradiol 25micrograms/24hours transdermal patches | £16.46 | 24 patch | 1 Oct 2026 |
NADAC: average price US retail pharmacies pay to buy the medicine. NHS Drug Tariff Part VIIIA: basic price reimbursed to pharmacies in England and Wales.
Safety signals and safety-related labeling changes
- US FDA 12 Feb 2026 BIJUVA — safety-related labeling change
Labeling sections changed: Boxed Warning; Contraindications; Warnings and Precautions; Adverse Reactions; Use in Specific Populations; Patient Counseling Information / Patient Information / Medication Guide - US FDA 12 Feb 2026 DIVIGEL — safety-related labeling change
Labeling sections changed: Boxed Warning; Contraindications; Warnings and Precautions; Adverse Reactions; Use in Specific Populations; Patient Counseling Information / Patient Information / Medication Guide - US FDA 12 Feb 2026 ESTRING — safety-related labeling change
Labeling sections changed: Contraindications; Warnings and Precautions - US FDA 5 May 2025 ALORA — safety-related labeling change
Labeling sections changed: Warnings and Precautions; Patient Counseling Information / Patient Information / Medication Guide - US FDA 10 Sep 2024 ESTRASORB — safety-related labeling change
Labeling sections changed: Boxed Warning; Warnings and Precautions; Use in Specific Populations - US FDA 26 Jun 2024 NATAZIA — safety-related labeling change
Labeling sections changed: Contraindications; Warnings and Precautions; Adverse Reactions; Use in Specific Populations; Patient Counseling Information / Patient Information / Medication Guide - US FDA 15 Feb 2024 ANGELIQ — safety-related labeling change
Labeling sections changed: Boxed Warning; Contraindications; Warnings and Precautions; Adverse Reactions; Use in Specific Populations; Patient Counseling Information / Patient Information / Medication Guide - US FDA 15 Feb 2024 ELESTRIN — safety-related labeling change
Labeling sections changed: Boxed Warning; Contraindications; Warnings and Precautions; Use in Specific Populations; Patient Counseling Information / Patient Information / Medication Guide - US FDA 15 Feb 2024 ESTROGEL — safety-related labeling change
Labeling sections changed: Boxed Warning; Contraindications; Warnings and Precautions; Drug Interactions; Use in Specific Populations; Patient Counseling Information / Patient Information / Medication Guide - US FDA 15 Feb 2024 EVAMIST — safety-related labeling change
Labeling sections changed: Boxed Warning; Warnings and Precautions; Use in Specific Populations; Patient Counseling Information / Patient Information / Medication Guide - US FDA 15 Feb 2024 MENOSTAR — safety-related labeling change
Labeling sections changed: Boxed Warning; Contraindications; Warnings and Precautions; Use in Specific Populations; Patient Counseling Information / Patient Information / Medication Guide - US FDA 15 Feb 2024 VAGIFEM — safety-related labeling change
Labeling sections changed: Boxed Warning; Warnings and Precautions; Adverse Reactions; Use in Specific Populations; Patient Counseling Information / Patient Information / Medication Guide - US FDA 15 Feb 2024 VIVELLE-DOT — safety-related labeling change
Labeling sections changed: Boxed Warning; Warnings and Precautions; Use in Specific Populations; Patient Counseling Information / Patient Information / Medication Guide - US FDA 15 Feb 2024 ACTIVELLA — safety-related labeling change
Labeling sections changed: Contraindications; Warnings and Precautions; Adverse Reactions; Drug Interactions; Use in Specific Populations; Patient Counseling Information / Patient Information / Medication Guide - US FDA 15 Feb 2024 CLIMARA PRO — safety-related labeling change
Labeling sections changed: Contraindications; Warnings and Precautions; Use in Specific Populations; Patient Counseling Information / Patient Information / Medication Guide
Combinations containing Estradiol
Values as published by each source: SFDA human drug list (4-2026, as published by the Council of Health Insurance; indications from the CHI Daman Drug Formulary), Drugs@FDA, EMA medicines data, Health Canada Drug Product Database (Open Government Licence – Canada), CMS NADAC, NHS Drug Tariff Part VIIIA (NHSBSA Copyright, Open Government Licence v3.0), WHO Model List of Essential Medicines (CC BY 3.0 IGO; regrouped by active substance, not created by WHO), EMA PRAC, US FDA safety-related labeling changes and MHRA Drug Safety Update (Open Government Licence v3.0). Sources and reuse. Not a substitute for the official registers or the product information.