Active substance
Nitrous oxide
- US FDA 7
- Health Canada 3
- WHO EML 1
- Safety 1
US FDA United States — FDA approvals (Drugs@FDA)
| Product | Strength | Form · route | Applicant | Status | First approved |
|---|---|---|---|---|---|
| NITROUS OXIDE, USP | N/A | gas · inhalation | AIR LIQUIDE AMERICA SPECIALITY GASES | Prescription | 16 Jun 2013 |
| NITROUS OXIDE, USP | N/A | gas · inhalation | NITROUS OXIDE CORP | Prescription | 3 Sep 2013 |
| NITROUS OXIDE, USP | N/A | gas · inhalation | NITROUS OXIDE OF CANADA | Prescription | 6 Sep 2013 |
| NITROUS OXIDE, USP | N/A | gas · inhalation | STRATA MEDICAL INNOVATIONS | Prescription | 25 Nov 2014 |
| NITROUS OXIDE, USP | N/A | gas · inhalation | MATHESON TRI-GAS INC | Prescription | 9 Jan 2017 |
| NITROUS OXIDE, USP | N/A | gas · inhalation | PRAXAIR DISTRIBUTION INC | Prescription | 6 Mar 2017 |
| NITROUS OXIDE, USP | N/A | gas · inhalation | LINDE GAS EQUIP | Prescription | 9 Aug 2026 |
Canada Canada — marketed products (Health Canada)
| Brand | DIN | Strength | Form · route | Company |
|---|---|---|---|---|
| NITROUS OXIDE 100% | 00572845 | 100 % | GAS · INHALATION | AIR LIQUIDE CANADA INC. |
| NITROUS OXIDE U.S.P. | 02154811 | 99 % | GAS · INHALATION | MESSER CANADA INC. |
| NITROUS OXIDE USP | 02014467 | 99 % | GAS · INHALATION | LINDE CANADA INC. |
WHO WHO Model List of Essential Medicines (2025)
- 1.1.1. General anaesthetics and oxygen > Inhalational medicines · core
Anaesthetics and therapeutic gases
Respiratory > Inhalation:
Safety signals and safety-related labeling changes
- MHRA 11 Dec 2014 Nitrous oxide: neurological and haematological toxic effects
Toxic effects can occur with nitrous oxide especially with prolonged use.
Values as published by each source: SFDA human drug list (4-2026, as published by the Council of Health Insurance; indications from the CHI Daman Drug Formulary), Drugs@FDA, EMA medicines data, Health Canada Drug Product Database (Open Government Licence – Canada), CMS NADAC, NHS Drug Tariff Part VIIIA (NHSBSA Copyright, Open Government Licence v3.0), WHO Model List of Essential Medicines (CC BY 3.0 IGO; regrouped by active substance, not created by WHO), EMA PRAC, US FDA safety-related labeling changes and MHRA Drug Safety Update (Open Government Licence v3.0). Sources and reuse. Not a substitute for the official registers or the product information.